; Young infants are at greatest risk for complications and even death from this respiratory disease.
[Medline]. Marconi GP, Ross LA, Nager AL. Sources of Infant Pertussis Infection in the United States. [Guideline] American Academy of Pediatric Committee on Infectious Diseases. 65 (5):811-818. Joseph J Bocka, MD Attending Emergency Physician, OhioHealth MedCentral Health System; Emergency Medical Service Medical Director, Multiple EMS Service; Ohio EMS RPAB Region Chair Liu BC, McIntyre P, Kaldor JM, Quinn H, Ridda I, Banks E. Pertussis in older adults: prospective study of risk factors and morbidity. Vol 1.
Infants More Likely to Contract Pertussis From Siblings. [Medline]. MMWR Morb Mortal Wkly Rep. 2007 Aug 24. Glanz JM, McClure DL, Magid DJ, Daley MF, France EK, Salmon DA, et al. 5th ed.
Accessed: June 17, 2014.
[42], For the latest childhood and adolescent immunization recommendations, see the CDC immunization schedules. Medical tests may be needed to confirm the diagnosis.
Available at http://www.medscape.com/viewarticle/777732. 50(10):1339-45.
For the hospitalized patient, in addition to standard precautions, droplet precautions are recommended for 5 days after initiation of effective therapy or until 3 weeks after the onset of paroxysms if appropriate antimicrobial therapy is not given. If treatment is started early in the course of illness (during the catarrhal stage), symptoms may be lessened. Outbreaks of respiratory illness mistakenly attributed to pertussis--New Hampshire, Massachusetts, and Tennessee, 2004-2006. Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older - United States, 2017.
Philadelphia, PA: Saunders; 2004:471-528. de Greeff SC, Mooi FR, Westerhof A, Verbakel JM, Peeters MF, Heuvelman CJ, et al.
Bisgard K. Background.
2012 Jul 20. The same regimen is used for both. [Guideline] Kim DK, Riley LE, Harriman KH, Hunter P, Bridges CB.
[34, 35] The FDA has licensed 2 tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) products for use in children aged 10-18 years (Boostrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) and for patients aged 11-64 years (Adacel; Sanofi Pasteur, Toronto, Canada). Consultation with subspecialists is usually not indicated; however, if the diagnosis is unclear or the clinical course warrants, infectious disease specialists or other subspecialists should be consulted. Medscape Medical News.
Available at http://www.medscape.com/viewarticle/850781. Pediatrics. Centers for Disease Control and Prevention; American Academy of Pediatrics Committee on Infectious Diseases.
Pediatr Infect Dis J. Cherry JD, Heininger U. Pertussis and other Bordetella Infections.
Source: Centers for Disease and Control. [38, 39] Crude estimates for preterm delivery were 6.3% among vaccinated women and 7.8% among unvaccinated women (adjusted risk ratio [RR] 1.03). Pertussis, or whooping cough, is an infection of the nose, throat, and lungs. Health Care Facilities, Providers, and Insurance, Healthy Communities, Environment and Workplaces, Pertussis Information for Health Professionals Home, Managing Pertussis: Think, Test, Treat & Stop Transmission, Follow-up Recommendations for Pertussis Exposures in the Health Care Setting, Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis, Infectious Disease Epidemiology, Prevention and Control Division, 10 mg/kg/day orally on the first day (maximum 500 mg), 5 mg/kg once daily on days 2-5 (maximum 250 mg/day), 500 mg orally on the first day, 250 mg once daily on days 2-5, not recommended for use in infants <6 months of age; see child dose for infants >6 months of age, 15 mg/kg/day orally divided into 2 doses/day for 7 days (maximum 1 g/day), Estolate preparation preferred if available, 40-50 mg/kg/day orally divided into 4 doses/day for 14 days (maximum 2 g/day), 2 g/day orally divided into 4 doses/day for 14 days, not recommended for use in children <2 months of age; see child dose for infants >2 months of age, 8 mg TMP/40 mg SMX/kg/day orally divided into 2 doses/day for 14 days (maximum 320mg TMP/1600mg SMX/ day), 320 mg TMP/1600 mg SMX per day orally divided into 2 doses/day for 14 days.
Pertussis (Whooping Cough): Outbreaks. 117(3):965-78. Murray E, Nieves D, Bradley J, et al. 2006 Mar. If you log out, you will be required to enter your username and password the next time you visit. Pay attention to the young infant's hydration and nutritional status.
[Medline]. Vaccination is now recommended with acellular pertussis vaccine plus diphtheria and tetanus toxoids (DTaP) at the ages of 2, 4, 6, and 15-18 months and at age 4-6 years.
Robinson CL, Romero JR, Kempe A, Pellegrini C, Advisory Committee on Immunization Practices (ACIP) Child/Adolescent Immunization Work Group. News, encoded search term (Pertussis) and Pertussis, Coronavirus Disease 2019 (COVID-19) in Children, Antibiotic Prophylactic Regimens for Endocarditis, Easier-to-Use Coronavirus Saliva Tests Start to Catch On. The study did find a small but statistically significant increased risk of chorioamnionitis with Tdap vaccination during pregnancy. Long-term effectiveness studies are ongoing. http://www.medscape.com/viewarticle/850781, http://www.cdc.gov/pertussis/outbreaks.html, http://www.cdc.gov/pertussis/surv-reporting.html, http://www.cnn.com/2014/06/13/health/whooping-cough-california/, http://www.cdc.gov/pertussis/outbreaks/trends.html, http://www.medscape.com/viewarticle/835898, http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5450a3.htm, http://www.medscape.com/viewarticle/777732, http://www.medscape.com/viewarticle/834849, https://www.cdc.gov/vaccines/imz-managers/coverage/adultvaxview/tdap-report-2016.html, http://www.cdc.gov/vaccines/schedules/index.html. Concern about CNS adverse effects is a major reason why many individuals chose not to be vaccinated. Pertussis. The bacterium Bordetella pertussis causes this respiratory infection. Centers for Disease Control and Prevention.
Centers for Disease Control and Prevention: Atlanta, GA, 2005.
This website also contains material copyrighted by 3rd parties. In: Feigin RD, Demmler GJ, Cherry JD, Kaplan SL. Harding A. Pertussis Vaccine Appears Safe in Pregnancy for Mom, Baby. In: Atkinson W, Wolfe S, Hamborsky. [Full Text].
Antibiotics may also prevent or alleviate secondary bacterial infection.
Because pertussis is toxin-mediated, symptoms do not necessarily resolve with treatment. Ideally, Tdap is recommended before pregnancy, but it may be given during pregnancy after 20 weeks’ gestation.
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