2001 Aug;100(2):240-9. doi: 10.1006/clim.2001.5058.
eISSN: 2326-6074 We also detected the presence of transcripts for its ligand, CSF1, but not IL34, in all tested LCH cases. In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells.
2013 Dec 1;208(11):1756-67. doi: 10.1093/infdis/jit362. Our assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis have undergone considerable changes. Lymphoid nodules were present in the submucosa of vagina (14 animals) and ectocervix (4 animals), and these nodules contained macrophages, CD4+ T cells and B cells, with fewer numbers of CD8+ T cells and Langerhans cells. Epub 2005 Aug 10. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. NIH
Epub 2014 Apr 16. Results: ©2020 American Association for Cancer Research. Get the latest research from NIH: https://www.nih.gov/coronavirus.
Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. C R Seances Soc Biol Fil. Symptoms range from isolated bone lesions to multisystem disease. [The functional morphology of the Langerhans cells in the female reproductive tract]. Langerhans cells are the prototypic nonlymphoid members of the dendritic cell family (Table 2).The cells in this family exhibit prominent dendritic morphology, characteristic phenotype (Table 3), and potent antigen-presenting cell capabilities.These features make this family of cells distinct from monocytes/macrophages and other bone marrow-derived cells. Epub 2013 Aug 1. CD1a+ Langerhans cells were present in the stratified squamous epithelium of the vagina (14 animals) and ectocervix (11 animals). You may purchase access to this article or login to access your subscription using the links below. 2005 Dec;73(6):1253-63. doi: 10.1095/biolreprod.105.043133. Micsenyi AM, Zony C, Alvarez RA, Durham ND, Chen BK, Klotman ME.
Hu J, Pope M, Brown C, O'Doherty U, Miller CJ. Conclusions: Targeting BRAF V600E in clonal Langerhans cells (LC) and their … This article requires a subscription to view the full text. Variable numbers of CD20+ B cells and CD4+ lymphocytes were located in the submucosa of all the areas examined. LCH is part of a group of syndromes called histiocytoses, which are characterized by an abnormal proliferation of histiocytes (an archaic term for activated dendritic cells and macrophages). The purpose of this investigation was to define the morphology of the mucosa-associated lymphoid tissue in the genital tract of rhesus monkeys. This pathway of antigen presenting cell migration from the mucosa to the genital lymph node may represent the inductive arm of the mucosal immune system in the lower female reproductive tract. In LCH clinical samples, LCH cells (including BRAFV600E cells) and TAMs retained high expression of CSF1R. LCs that were differentiated from CD14+ monocytes, BDCA1+ DCs, and CD34+ cord blood progenitors expressed CSF1R that was downregulated upon maturation. PLoS One. 1994;188(3):207-21. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail.
Administration of the c-FMS/CSF1R kinase inhibitors GW2580 and BLZ945 significantly reduced human LC migration. 2015 Apr 15;68(5):511-8. doi: 10.1097/QAI.0000000000000531. | Thank you for sharing this Cancer Immunology Research article. Biol Reprod. Langerhans cells in the vaginal mucosa and endocervix may be well suited to sample antigen in the lumen of the reproductive tract, travel to the draining lymph node, present the antigen to T lymphocytes and initiate an immune response. Michel KG, Huijbregts RP, Gleason JL, Richter HE, Hel Z. J Acquir Immune Defic Syndr.
Sasikala-Appukuttan AK, Kim HO, Kinzel NJ, Hong JJ, Smith AJ, Wagstaff R, Reilly C, Piatak M Jr, Lifson JD, Reeves RK, Johnson RP, Haase AT, Skinner PJ. Immunophenotypic characterization of simian immunodeficiency virus-infected dendritic cells in cervix, vagina, and draining lymph nodes of rhesus monkeys. Please enable it to take advantage of the complete set of features! doi: 10.1371/journal.pone.0081623. In all of the animals, moderate numbers of CD8+ lymphocytes were present in the submucosa and squamous epithelia of the vagina and ectocervix. Targeting BRAFV600E in clonal Langerhans cells (LC) and their precursors is a potential treatment option for patients whose tumors have the mutation. CSF1R and CSF1 expression in LCH, and their role in LC migration and differentiation, suggests CSF1R signaling blockade as a candidate rational approach for treatment of LCH, including the BRAFV600E and wild-type forms of the disease. Surprisingly, CD1a+ dendritic cells were also found within the columnar epithelium of the endocervix (5 animals).
Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone.
Copyright © 2020 by the American Association for Cancer Research. Liu A, Yang Y, Liu L, Meng Z, Li L, Qiu C, Xu J, Zhang X. PLoS One. For many years, LCs have been assumed to be DCs due to its migratory capabilities. NLM The lower reproductive tract is an important site of contact with pathogenic microorganisms and local immune responses to a variety of antigens have been reported. In LCH, somatic mutations of the BRAFV600E gene have been detected in tissue LCH cells, bone marrow CD34+ hematopoietic stem cells, circulating CD14+ monocytes, and BDCA1+ myeloid dendritic cells (DC). LCs are members of the dendritic cell (DC)/macrophage family, and the… Variable numbers of CD20+ B cells and CD4+ lymphocytes were located in the submucosa of all the areas examined. Immature LCs migrated toward CSF1, but not IL34. doi: 10.1371/journal.pone.0085176. Experimental design: HHS CSF1R Is Required for Differentiation and Migration of Langerhans Cells and Langerhans Cell Histiocytosis, Gut Microbiome Impact on ICI Efficacy in Patients with NSCLC, Gut Microbiome Is Associated with Anti–PD-1/PD-L1 Responses, Cancer Epidemiology, Biomarkers & Prevention, Disclosure of Potential Conflicts of Interest. 2013 Dec 9;8(12):e81623. The identity of Langerhans cells (LCs) has been called into question of late due to the increasing evidence that LCs originate from macrophage lineage instead of dendritic cell (DC) lineage as previously thought. Clipboard, Search History, and several other advanced features are temporarily unavailable. Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. COVID-19 is an emerging, rapidly evolving situation. | This will require you to, Sign In to Email Alerts with your Email Address. Differential compartmentalization of HIV-targeting immune cells in inner and outer foreskin tissue. Moderate numbers of CD68+ macrophages were located in the submucosa of the vagina, ectocervix, and endocervix of all the monkeys. Langerhans cells (LCs) are resident macrophages in skin epidermis, where they have immune-stimulatory capacities. Clin Immunol. | Background:
The number and distribution of immune cells in the cervicovaginal mucosa remain constant throughout the menstrual cycle of rhesus macaques. One of the key cellular components with functional roles in both innate and adaptive arms of the immune response are Langerhans cells (LCs) (2). Am J Reprod Immunol. We do not retain these email addresses. Langerhans cell histiocytosis (LCH) is a rare cancer involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Get the latest public health information from CDC: https://www.coronavirus.gov. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Once thought to be prototypic representatives of the dendritic cell (DC) lineage, they are now considered to be a specialized subset of tissue-resident macrophages.
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In patients with diffuse-type tenosynovial giant cell tumors, CSF1R inhibition depletes tumor-associated macrophages (TAM) with therapeutic efficacy; however, CSF1R signaling in LCs and LCH has not been investigated. The development of mouse macrophages and LCs is regulated by the CSF1 receptor (CSF1R). Langerhans cell histiocytosis (LCH) is a rare disorder characterized by tissue accumulation of CD1a+CD207+ LCH cells. Monoclonal antibodies were used in an immunoperoxidase staining technique to identify immunophenotypic markers on mononuclear cells in the vaginal and cervical mucosa of 14 cycling, multiparous rhesus macaques. Langerhans cell histiocytosis (LCH) is a rare disorder characterized by tissue accumulation of CD1a+CD207+ LCH cells. Note: Supplementary data for this article are available at Cancer Immunology Research Online (http://cancerimmunolres.aacrjournals.org/). International Agency for Research on Cancer - Screening Group, NCI CPTC Antibody Characterization Program. Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens. 2014 Jan 15;9(1):e85176. Cancer Immunology Research Under both steady and inflammatory conditions, upon activation, LCs migrate from the epidermis to the skin-draining lymph nodes to present antigens to T cells, resulting in the activation of acquired immunity (Hemmi et al., 2001; Merad et al., 2008; Romani et al., 2010; … Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract. J Infect Dis. We found through IHC and flow cytometry that CSF1R is normally expressed on human CD1a+CD207+ LCs in the epidermis and stratified epithelia. Lymphoid nodules were present in the submucosa of vagina (14 animals) and ectocervix (4 animals), and these nodules contained macrophages, CD4+ T cells and B cells, with fewer numbers of CD8+ T cells and Langerhans cells. These observations provide a morphologic basis for mucosa-associated lymphoid tissue in the female genital tract.
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