Consider therapy modification, Estrogen Derivatives: May diminish the therapeutic effect of Hyaluronidase. Daratumumab is an IgG1κ human monoclonal antibody directed against CD38.
Management: Avoid the use of hyaluronidase to enhance dispersion or absorption of alpha-/beta-agonists. Baricitinib: Immunosuppressants may enhance the immunosuppressive effect of Baricitinib. Immunosuppressants may diminish the therapeutic effect of Vaccines (Live). Severe reactions included hypoxia, dyspnea, hypertension, and tachycardia; other signs/symptoms of systemic reactions may include respiratory symptoms (eg, bronchospasm, nasal congestion, cough, throat irritation, allergic rhinitis, wheezing), as well as anaphylactic reaction, pruritis, fever, chills, nausea, vomiting, chest pain, and hypotension. Assess patients for current or prior HBV infection. Consider therapy modification, Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines (Live). Daratumumab (for IV administration) and daratumumab/hyaluronidase (for subcutaneous administration) are not interchangeable; check vial labels to prevent medication errors. Other side effects of this drug: Talk with your doctor right away if you have any of these signs of: • Bleeding like vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in your urine; black, red, or tarry stools; bleeding from the gums; menstruation; bruises without a reason or that get bigger; or any severe or persistent bleeding, • Low calcium like muscle cramps or spasms, numbness and tingling, or seizures, • High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit. Do not substitute daratumumab (IV) with daratumumab/hyaluronidase (for subcutaneous use); products have different dosing and are not interchangeable. Consider therapy modification, Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. [4], In November 2015, the U.S. Food and Drug Administration (FDA) approved daratumumab for treatment of multiple myeloma in people who had received at least three prior therapies. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Combination therapy: Consider administering oral methylprednisolone ≤20 mg (or equivalent) beginning the day after the daratumumab/hyaluronidase dose. Word of the day - in your inbox every day, © 2020 HowToPronounce. Solutions diluted for infusion should be administered immediately at room temperature and in room light; diluted solution may be kept at room temperature for a maximum of 15 hours (including infusion time). Gently invert to mix (do not shake). It lists many things about each drug, including theâ¦, A drug used to treat certain bacterial skin and bloodstream infections in adults. Consult drug interactions database for more information. [8], In May 2018, the FDA expanded the approval of daratumumab for use in combination with bortezomib, melphalan and prednisone to include the treatment of people with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. You've got the pronunciation of daratumumab right. Management: Consider avoiding Echinacea in patients receiving therapeutic immunosuppressants.
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