Prevention and control of influenza. Bone marrow versus peripheral blood as the stem cell source for sibling transplants in acquired aplastic anemia: survival advantage for bone marrow in all age groups. 7. Unless otherwise noted, the recommendations presented in this report address allogeneic and autologous, and pediatric and adult HCT recipients. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.
8. Immunoglobulin prophylaxis in hematopoietic stem cell transplantation: systematic review and meta-analysis. The current recommendations consider myeloablative and reduced-intensity conditioning for allogeneic HCT to be similar, as data on infectious complications after reduced-intensity conditioning compared with myeloablative conditioning are sparse.4–7 However, increased information regarding post transplant immune recovery highlighting differences between myeloablative and reduced-intensity HCT is included. These changes are fuelled by new antimicrobial agents, increased knowledge of immune reconstitution and expanded conditioning regimens and patient populations eligible for HCT. PubMed Google Scholar. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0), We use cookies to help provide and enhance our service and tailor content and ads. Recommendations for a standard UK approach to incorporating umbilical cord blood into clinical transplantation practice: an update on cord blood unit selection, donor selection algorithms and conditioning protocols. They do not include a formal grading of the evidence. The final 5 recommendations focus on graft source for patients with aplastic anemia, corticosteroid dose for initial treatment of graft-versus-host-disease, optimal number of umbilical cord blood units for transplantation, graft source in matched unrelated donor transplantation, and use of prophylactic intravenous immunoglobulin in transplant recipients. © 2018 American Society for Blood and Marrow Transplantation. These include information on multiple organisms that were previously not discussed but have seemingly become more clinically relevant in HCT patients over the past decade. Center for International Blood and Marrow Transplant Research (CIBMTR); National Marrow Donor Program (NMDP); European Blood and Marrow Transplant Group (EBMT); American Society of Blood and Marrow Transplantation (ASBMT); Canadian Blood and Marrow Transplant … 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. BMT is a treatment option for selected patients with aplastic anemia. Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome. The ASBMT/EBMT guidelines for preventing infectious complications among BMT recipients recommend against the routine use of immunoglobulin replacement for prophylaxis of bacterial infections before or after 100 days of transplantation, unless profound hypogammaglobulinemia (IgG < 400 mg/L) is identified . | Don't use greater than 2 mg/kg/day of methylprednisolone (or equivalent) for the initial treatment of GVHD. | Data and, where possible, recommendations are provided regarding the following organisms that were not included in the previous document: Bordetella pertussis; polyomaviruses, BK and JC; hepatitis A, B and C viruses; human herpesviruses 6, 7 and 8; human metapneumovirus; HIV; tuberculosis; nocardiosis; malaria; and leishmaniasis.
Siegel JD, Rhinehart E, Jackson M, Chiarello L. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings. Guidelines on the use of intravenous immune globulin for hematologic conditions. Viral cultures of asymptomatic HCT candidates are unlikely to be useful.
Despite these advances, infection is reported as the primary cause of death in 8% of autologous HCT patients and in 17–20% of allogeneic HCT recipients.3 The major changes in this document, including changes in recommendation ratings, are summarized here. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. By continuing you agree to the Use of Cookies. In updating these guidelines, the committee sought to summarize the currently available data and present them as concisely as possible in an evidence-based manner. (2020), Bone Marrow Transplantation As a result of a consensus discussion, the Italian Association for Pediatric Hematology-Oncology (AIEOP) Cooperative Group centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while … the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Several topics are new or expanded from the previous document (Table 2). Some limitations of published guidelines must be acknowledged, such as the inclusion of lower quality nonrandomized studies, those with only laboratory-based surrogate endpoints, and older studies where the BMT population and supportive care may be less relevant to present-day BMT practice [.
Bone Marrow Transplant. Financial disclosure: See Acknowledgments on page 912. If an outbreak occurs with an influenza strain that is not contained in the available influenza vaccine, all healthy family members, close and household contacts, and HCWs of HCT recipients and candidates should receive influenza chemoprophylaxis with an active agent against the current circulating strain of influenza until the end of the outbreak8. The ASH Choosing Wisely(R) campaign: five hematologic tests and treatments to question. Infect Control Hosp Epidemiol. A systematic review, which included 9 randomized controlled trials and 1521 related and unrelated donor allogeneic BMT recipients with hematologic malignancies, demonstrated that overall survival and disease-free survival between the 2 graft sources were comparable [. volume 44, pages453–455(2009)Cite this article. Zanamivir may be given for prevention of influenza A and B, including influenza from strains resistant to oseltamivir. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.
You are using a browser version with limited support for CSS. January 14, Suggestions for BMT practices to question were elicited from the CBMTG Program Directors; from members of ASBMT's Quality Outcomes, Practice Guidelines, and Education committees; and from chairs of the CIBMTR scientific working committees. 1. Although considerable effort has gone into ensuring that the guidelines have a global perspective on the basis of currently available medical evidence, adherence to a particular recommendation may be inconsistent with national or regional guidelines, the availability of specific procedures or medications or local epidemiological conditions. Biol Blood Marrow Transplant. Whether multiplex PCR testing can identify asymptomatic shedders before HCT is presently being studied. 2018.
Combination therapy with aerosolized ribavirin and intravenous immunoglobulin for respiratory syncytial virus disease in adult bone marrow transplant recipients. This article contains highlights of “Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients: Recommendations of the CDC, the Infectious Diseases Society of America, and the American Society of Blood and Marrow Transplantation,” which was published in the Morbidity and Mortality Weekly Report. In addition, the recommendations for contact precautions (AIII), vaccination (BI) and prophylaxis for patients with GVHD (AIII) against Streptococcus pneumoniae have been strengthened. Guidelines on standard precautions as well as precautions to avoid transmission of specific infectious agents are available. 4. Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA, Centers for Disease Control and Prevention, Atlanta, GA, USA, Universitatsklinik Wurzburg Medizinische Klinik und Poliklinik II, Wurzburg, Germany, National Institutes of Health, Bethesda, MD, USA, Memorial Sloan Kettering Cancer Center, New York, NY, USA, Department of Medicine, Oncology, Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Department of Hematology and Oncology, University of Florida, Gainesville, FL, USA, Division of Infectious Diseases, University of Minnesota, Minneapolis, MN, USA, University of Washington Fred Hutchinson Cancer Research Center, Seattle, WA, USA, You can also search for this author in
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