[37] Sedation, respiratory depression and hypotension due to a reduction in systematic vascular resistance, and an increase in heart rate can occur.
[41], Although the incidence of respiratory depression/arrest is low (0.1–0.5%) when midazolam is administered alone at normal doses,[42][43] the concomitant use with CNS acting drugs, mainly analgesic opiates, may increase the possibility of hypotension, respiratory depression, respiratory arrest, and death, even at therapeutic doses. “Affect” vs. “Effect”: Use The Correct Word Every Time. It is not clear which drug or drugs caused his death or what quantities of vecuronium bromide and potassium chloride were released before the execution was cancelled. All the latest wordy news, linguistic insights, offers and competitions every month. [6] Midazolam can be given by mouth, intravenously, or injection into a muscle, by spraying into the nose, or through the cheek. [36] After nighttime administration of midazolam, residual 'hangover' effects, such as sleepiness and impaired psychomotor and cognitive functions, may persist into the next day. Disclaimer. [16][17][18], Intravenous midazolam is indicated for procedural sedation (often in combination with an opioid, such as fentanyl), for preoperative sedation, for the induction of general anesthesia, and for sedation of people who are ventilated in critical care units. adj. It will take a few weeks before the fracture starts to.
Today, 9 October, is the penultimate day of this year’s World Space Week, a UN event launched in 1999. When this occurs, the individual may experience anxiety, involuntary movements, aggressive or violent behavior, uncontrollable crying or verbalization, and other similar effects. [7] It is unclear whether full recovery occurs after longer periods of abstinence. [5], In October 2016, the U.S. state of Ohio announced that it would resume executions in January 2017, using the midazolam-vecuronium bromide-potassium chloride cocktail, but this was blocked by a Federal judge. : from French versé or Latin versatus , past participle of versari ‘be engaged in’. a composition written in metrical feet forming rhythmical lines, Line, line of a poem, Poem, poetical work, poetry, rhyme, Section, Song, stanza, stave, strophe, verse form, verse line, versification, poesy, Disclaimer: Urduwire.com is only the source of Urdu Meta News (type of Google News) and display news on “as it is” based from
From moonshoot to balconing: discover the latest words added to the Collins Dictionary. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Treatment is supportive; activated charcoal can be used within an hour of the overdose. The online version of the Collins Dictionary has just been updated again, with another batch of new words and meanings inspired by the events of the summer. [7] Midazolam is metabolised by cytochrome P450 (CYP) enzymes and by glucuronide conjugation. [5] Midazolam acts as a sedative to render the condemned prisoner unconscious, at which time the vecuronium bromide and potassium chloride are administered, stopping the prisoner's breathing and heart, respectively.
The risk factors for dependence include dependent personality, use of a benzodiazepine that is short-acting, high potency and long-term use of benzodiazepines. Which of the following does a coleopterist like? [7] Paradoxical excitement occasionally occurs with benzodiazepines, including a worsening of seizures. [90] A previous attempt in 2017 to halt an execution in the state of Arizona by another drug manufacturer was not successful.
[8][9] It belongs to the benzodiazepine class of drugs and works by increasing the activity of the GABA neurotransmitter in the brain. Midazolam is also sometimes used in newborns who are receiving mechanical ventilation, although morphine is preferred, owing to its better safety profile for this indication. [81], The execution of Ronald Bert Smith in Alabama on December 8, 2016 "went awry soon after (midazolam) was administered"[82]
Children and elderly individuals or those with a history of alcohol abuse and individuals with a history of aggressive behavior or anger are at increased risk of paradoxical effects. Why Do “Left” And “Right” Mean Liberal And Conservative? [57], Midazolam is a short-acting benzodiazepine in adults with an elimination half-life of 1.5–2.5 hours.
1. an injectable form of benzodiazepine (trade name Versed) useful for sedation and for reducing pain during uncomfortable medical procedures Familiarity information: VERSED used as a noun is very rare. The therapeutic as well as adverse effects of midazolam are due to its effects on the GABAA receptors; midazolam does not activate GABAA receptors directly but, as with other benzodiazepines, it enhances the effect of the neurotransmitter GABA on the GABAA receptors (↑ frequency of Cl− channel opening) resulting in neural inhibition. It is a spot full of traditions, and well suited to any poet's residence, most of all for one so versed in New England legends. [35], Long-term use of benzodiazepines has been associated with long-lasting deficits of memory, and show only partial recovery six months after stopping benzodiazepines. Midazolam is sometimes used for the acute management of seizures. Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012, experienced; practiced; skilled; learned (usually followed by, thoroughly knowledgeable (about), acquainted (with), or skilled (in), Families and Physicians Debate the True Meaning of Brain Death, A Catechism of Familiar Things; Their History, and the Events Which Led to Their Discovery, Scientific American Supplement, Vol. Tolerance develops rapidly to the anticonvulsant effect, and the dose may need to be increased by several times to maintain anticonvulsant therapeutic effects. A "midazolam infusion syndrome" may result from high doses, and is characterised by delayed arousal hours to days after discontinuation of midazolam, and may lead to an increase in the length of ventilatory support needed. • VERSED (noun) The noun VERSED has 1 sense:.
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