mycobacterium vaccae in soil

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177973/, This idea goes all the way back to 1989 when British Scientist David Strachan first suggested his ‘hygiene hypothesis.’. Source: https://pubmed.ncbi.nlm.nih.gov/15151947/. Any campus photos that do not depict current safety practices were taken prior to COVID-19 public health orders and guidelines. A global team of researchers led by a CU Boulder professor has received a $1.5 million National Science Foundation grant to study the classic-period collapse in Mesoamerica.

For the new study, Lowry and his team identified, isolated and chemically synthesized a novel lipid, or fatty acid, called 10(Z)-hexadecenoic acid found in Mycobacterium vaccae. “We are just beginning to see the tip of the iceberg in terms of identifying the mechanisms through which they have evolved to keep us healthy. Lowry has published numerous studies demonstrating a link between exposure to healthy bacteria and mental health. Read More: Top Lawn Care Tips for a Greener Garden.

“It seems that these bacteria we co-evolved with have a trick up their sleeve,” said Lowry. This substance has been under heavy scrutiny by the scientific community over the past few years due to its potential positive health benefits. “This is just one strain of one species of one type of bacterium that is found in the soil but there are millions of other strains in soils,” Lowry said. “This is a huge step forward for us because it identifies an active component of the bacteria and the receptor for this active component in the host,” Professor Lowry said. “The idea is that as humans have moved away from farms and an agricultural or hunter-gatherer existence into cities, we have lost contact with organisms that served to regulate our immune system and suppress inappropriate inflammation,” said Professor Christopher Lowry, from the University of Colorado, Boulder, and the inVIVO Planetary Health of the Worldwide Universities Network. As one of the biggest proponents of this new domain of health science, Lowry put it best when he said that we’re just beginning to open our eyes to the ways in which these bacterium have evolved to keep us healthy. Source: https://pubmed.ncbi.nlm.nih.gov/31119329/. Thirty years after scientists coined the term “hygiene hypothesis” to suggest that increased exposure to microorganisms could benefit health, CU Boulder researchers have identified an anti-inflammatory fat in a soil-dwelling bacterium that may be responsible. The bacterium is found in soil and may stimulate serotonin production, which makes you relaxed and happier. “This is a huge step forward for us because it identifies an active component of the bacteria and the receptor for this active component in the host,” he said. Scholars aim to unlock mystery of the Mesoamerican collapse, Former CU Boulder postdoc Jennifer Doudna smashes glass ceiling with historic Nobel win, Children heavily influenced by time in nature, social and emotional support. Sci-News.com. The initiative, which is called The Showerhead Microbiome Project, is collecting samples of water from showerheads across the US and Europe to see how many mycobacteria, especially M. vaccae, are living there.

Source: https://www.pnas.org/content/113/22/E3130.

“It seems that these bacteria we co-evolved with have a trick up their sleeve,” Professor Lowry said. The benefits of this bacterium were first discovered fairly recently (depending on what you define as recently of course…). CU Boulder Today is created by Strategic Relations and Communications. Breathing in dirt-laced air, playing in dirt, digging around in dirt, anything really. During the study, O’Brien and her team had injected several lung cancer patients with the bacterium to see if it had any life-prolonging effects. Others have shown that when a particular soil-dwelling bacterium, Mycobacterium vaccae, is injected into rodents, it alters the animals’ behavior in a way similar to that of antidepressants and has long-lasting anti-inflammatory effects on the brain.

From the evidence that’s been gathered to this point, one thing is pretty clear: dirt could very well be good for your health while our modern life, which is spent in sterilised, sealed-off buildings and homes is most likely not. If you’d love to boost your health but aren’t fortunate enough to have a garden or don’t have much of a green-thumb there are alternate ways to get your dose of M. vaccae. They discovered that inside cells, the lipid acted like a key in a lock, binding to a specific receptor, peroxisome proliferator-activated receptor, and inhibiting a host of key pathways which drive inflammation.

The researchers have long envisioned developing a ‘stress vaccine’ from Mycobacterium vaccae, which could be given to first responders, soldiers and others in high-stress jobs to help them fend off the psychological damage of stress. The results were published in the journal Psychopharmacology. In tests done on rats, both injection and ingestion of M. vaccae resulted in better cognitive ability, lower stress levels, and increased concentration when compared to their untreated counterparts. This bacterium with a potentially natural antidepressant quality which is found in soil, is called Mycobacterium vaccae. Simply knowing the mechanism of action by which M. vaccae reaps benefits could boost confidence in it as a potential therapeutic. But why is this bacterium found in so many places? The Difference Between Halogen / Quartz / Tungsten / Short / Medium / Far Infrared Patio Heaters? As I huff the soil, I have no way of knowing exactly how much M. vaccae is floating into my lungs -- or whether it's enough to change my mind. We do have some of the best minds on the case, however, as Lowry, the scientist from Bristol, has inspected 300 soil samples from around the US and Europe to learn more about our tiny little bacterial friends. One showed that children raised in a rural environment, surrounded by animals and bacteria-laden dust, grow up to have more stress-resilient immune systems and may be at lower risk of mental illness than pet-free city dwellers. This, all possible because when we interact with the dirt, soil, and nature of our environment, we come into contact with the beneficial bacterium that is M. vaccae. Later, in 2007, a neuroscientist at the University of Bristol named Christopher Lowry injected M. vaccae into mice subjecting them to several stress tests. (Studies suggest exaggerated inflammation boosts risk of stress-related disorders, such as posttraumatic stress disorder.) The discovery, published Monday in the journal Psychopharmacology, may at least partly explain how the bacterium, Mycobacterium vaccae, quells stress-related disorders.
Thirty years after beginning her training as a postdoctoral scholar in the CU Boulder lab of Nobel laureate Thomas Cech, biochemist Jennifer Doudna on Wednesday won her own Nobel Prize for Chemistry for the co-development of the revolutionary genome editing tool CRISPR-Cas9.

Discovery of M. Vaccae & Studies On Its Benefits, The Positive Health Benefits of Mycobacterium Vaccae-Rich Soil, How To Get More Good Soil Bacterium In Your Life, https://pubmed.ncbi.nlm.nih.gov/15151947/, https://pubmed.ncbi.nlm.nih.gov/31119329/, https://www.pnas.org/content/113/22/E3130, https://mbio.asm.org/content/9/5/e01614-18, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177973/. Professor David Strachan from the London School of Hygiene and Tropical Medicine first proposed the hygiene hypothesis in 1989, suggesting that in our modern, sterile world, lack of exposure to microorganisms in childhood was leading to impaired immune systems and higher rates of allergies and asthma.

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