That means one form of cancer can break away Having established the relationship between growth fraction and drug sensitivity, we can apply this knowledge to predict how specific cancers will respond to chemotherapy. Foremost among these is the serious and unavoidable toxicity to normal cells caused by cytotoxic drugs. Hair, GI, skin, reproductive, bone marrow. Enjoy your full access to all video lectures, quiz questions, articles and the board-style Qbank for the next 24 hours FOR FREE. Detection at this stage cannot be considered early.
In this chapter, our discussion of anticancer drugs pertains almost exclusively to the cytotoxic agents. It was once believed that cancer cells divided more rapidly than normal cells and that this excessive rate of division was responsible for the abnormal growth patterns of cancerous tissues. but I wanna give you a little introduction to what cancer is. A tissue with a large percentage of proliferating cells and few cells in G0 has a high growth fraction. Consequently, before we discuss the anticancer drugs, we must first understand the growth fraction.
Beginning at age 50, men and women should follow one of the 7 examination schedules below. Host defenses contribute little to cell kill. For patients with some forms of cancer (Table 101–2), drugs can often be curative. Once a cancer has been reduced to less than 1 billion cells, it becomes undetectable by usual clinical methods; all signs of disease are absent, and the patient is considered in complete remission.
View Principles of chemotherapy.ppt from PHARMACY 1101214 at University of Sharjah. To cure a patient of cancer, we must eliminate virtually every malignant cell. Because if it sticks in your mind, that's what matters to me. 30,220 ‡Chemotherapy is combined with surgery and/or radiotherapy in these cancers.
01:05 and travel through the body and form cancer in other areas. In any tissue, some cells are going through the cell cycle, whereas others are “resting” in G0. Hence, even if a cancer has 1 billion cells when it’s detected, that’s still far better than a gazillion. https://doi.org/10.1016/j.paed.2009.10.003. Now, I'm gonna do something with you right now that you're gonna think is kinda weird. Chemotherapy drugs cause cell death by apoptosis, either by directly interfering with DNA, or by targeting the key proteins required for cell division. That's where we're gonna focus. Because just one remaining cell can proliferate and cause relapse. they feel terrible, we let them recover, right? Breast
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