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It is already known that zebrafish can flexibly regenerate their hearts after injury.
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Suppl. In a next step, the authors would like to unravel the role of sox10 in this cell population: "We want to find out whether the absence of such a sox10 cell population in mammals could explain why their heart does not regenerate well," explains Mercader. If this is the case, the researchers believe that this finding could be of great importance in stimulating the repair process in the human heart. Mol. PLoS ONE 5, e11134 (2010). Hare, J. M. et al. Heart regeneration is well documented in amphibia and fish and in developing mammals. Messina, E. et al. Olivetti, G. et al. J. Clin. Bersell, K., Arab, S., Haring, B. OHSU is an equal opportunity affirmative action institution. Hassink, R. J. et al. This paper describes the guided differentiation and isolation of multipotent cardiovascular progenitor cells from human ESCs. Kajstura, J. et al. Nature Nature Med. 68, 1560–1568 (1991).
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Through advances in regenerative medicine, the health care economy could save hundreds of thousands of dollars per heart failure patient – and give the patient a better, healthier life. J.
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