Stem Cells 23:791–804. Abarbanell AM, Wang Y, Herrmann JL, Weil BR, Poynter JA, Manukyan MC, Meldrum DR. Am J Physiol Heart Circ Physiol. doi: Robertson C, Tran DD, George SC (2013) Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. c-kitPOS cells were negative for these skeletal muscle transcription factors. doi: Rudy-Reil D, Lough J (2004) Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells. A normal wave can be seen in the sham group. 2011 Nov 26;378(9806):1827-8. doi: 10.1016/S0140-6736(11)61648-6.
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Nature 336:688–690. Clearly, after many doublings in culture, cardiac Lin, The in vivo results described above do not address whether the Lin, Cloning by dilution technique does not assure a single cell origin of the clones harvested. The lack of cell fusion was confirmed by the Cre-lox strategy. (J) Reappearance of contraction at 19 days (arrowheads). doi: Chambers I, Colby D, Robertson M et al (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Am J Physiol Regul Integr Comp Physiol.
New York Heart Association (NYHA) functional class (. Blood, in press. Circ Res 100:263–272. Primitive cells of donor and recipient origin that express stem cell-related surface antigens—c-kit, Sca-1, and MDR1—were identified in the recipient hearts.
doi: Kim HS, Cho JW, Hidaka K, Morisaki T (2007) Activation of MEK-ERK by heregulin-beta1 promotes the development of cardiomyocytes derived from ES cells. 2015 Jun 26;7(5):793-805. doi: 10.4252/wjsc.v7.i5.793. USA.gov.
Transmission electron photomicrograph of hucMSC-exosomes (a). Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin. Prog Biophys Mol Biol 110:178–195. Cell Physiol Biochem 18:303–314. Identification of exosomes derived from hucMSC. 2020 Apr 29;11(2):e0015. They suggest that intracoronary infusion of autologous CSCs is effective in improving LV systolic function and reducing infarct size in patients with heart failure after myocardial infarction, and warrant further, larger, phase 2 studies. doi: 10.1093/eurheartj/ehr435. Cardiac stem cells in patients with ischaemic cardiomyopathy. Stem Cells and Myocardial Repair. Proc Natl Acad Sci U S A 75:5565–5569, Sudou A, Muramatsu H, Kaname T et al (1997) Le(X) structure enhances myocardial differentiation from embryonic stem cells.
Circ Res 91:501–508. Discov Med 15:349–356, Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. doi: Snir M, Kehat I, Gepstein A et al (2003) Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Passier R, van Laake LW, Mummery CL (2008) Stem-cell-based therapy and lessons from the heart. Cardiac cells were isolated from female Fischer rats at 20–25 months of age. Evidence that human cardiac myocytes divide after myocardial infarction. Cell based therapy (CBT) provides an alternative option to replace damaged myocardium and vasculature and restore cardiac contractility. Genetic dissection of cardiac growth control pathways. Pfister O, Della Verde G, Liao R, Kuster GM (2014) Regenerative therapy for cardiovascular disease. Circ Res 88:1004–1011, Pera MF, Reubinoff B, Trounson A (2000) Human embryonic stem cells. This site needs JavaScript to work properly. Kaushal S, Jacobs JP, Gossett JG, Steele A, Steele P, Davis CR, Pahl E, Vijayan K, Asante-Korang A, Boucek RJ, Backer CL, Wold LE. Fisher SA, Brunskill SJ, Doree C, Mathur A, Taggart DP, Martin-Rendon E. Cochrane Database Syst Rev. 2020 Aug 13;8:972. doi: 10.3389/fbioe.2020.00972. Sun et al. Huh NE, Pasumarthi KB, Soonpaa MH et al (2001) Functional abrogation of p53 is required for T-Ag induced proliferation in cardiomyocytes.
( A and B ) Scatter plots of hCSCs ( A…, hCSCs regenerate infarcted myocardium. Get the latest research from NIH: https://www.nih.gov/coronavirus. (D) Accumulation of nestin (yellow) in spheroids. Trial profile showing a summary of screening, exclusions, and enrollment. A clonal analysis can distinguish between these alternatives. c-kitPOS cells were negative for these neural proteins. Part of Springer Nature. © 2020 Springer Nature Switzerland AG.
2020 Sep 16;14:3765-3775. doi: 10.2147/DDDT.S239546. Please enable it to take advantage of the complete set of features! doi: Mitsui K, Tokuzawa Y, Itoh H et al (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Biology of hematopoietic stem cells and progenitors. eCollection 2020.
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( A ) Human myocytes are Cre-recombinase-positive (white) but…, NLM Trial profile showing a summary of screening, exclusions, and enrollment.
Circulation 107:1912–1916. PLoS One 6, e23657. J Cardiovasc Transl Res 5:555–565. doi: Behfar A, Zingman LV, Hodgson DM et al (2002) Stem cell differentiation requires a paracrine pathway in the heart. (A)–(C) show c-kitPOS cells (green). Cells tested at later passages (P19 and P26) exhibited similar differentiation profiles. Heart Fail Rev 18:815–833. J Mol Cell Cardiol 29:1525–1539. The purported plasticity and multipotency of some stem cells, such as those from the bone marrow, and their capacity to differentiate into cell types other than those of their tissue of origin, as reported by us and many others, has been thrown into doubt by the recent demonstration that under some situations certain stem cells have a tendency to fuse in vitro and with the differentiated cells of the host organ in vivo (see. Umbilical Cord Mesenchymal Stem Cell-Derived Nanovesicles Potentiate the Bone-Formation Efficacy of Bone Morphogenetic Protein 2. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Contemporary perspective on endogenous myocardial regeneration.
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance.
At P0 and P1, when grown in DM, 30% of the cells had detectable GATA-4 in the nucleus and 55% expressed GATA-5; 50% were positive for Nkx2.5 and 60% for MEF2. This service is more advanced with JavaScript available, Stem Cells and Cardiac Regeneration Cell. August 22, doi: Sachinidis A, Schwengberg S, Hippler-Altenburg R et al (2006) Identification of small signalling molecules promoting cardiac-specific differentiation of mouse embryonic stem cells. At 10 days, there were 49 ± 11 arterioles and 595 ± 103 capillaries per mm, The new myocardial cells positively affected cardiac performance. Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts.
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