-, Transplant Proc. Reproductive failure (recurrent miscarriages and pre-eclampsia) Group 2 HLA-C alleles (C2). -, Contemp Top Immunobiol. Idiotype-like determinants on human T lymphocytes alloactivated in mixed lymphocyte culture. 1977;7:69-112 The generation and maintenance of serum alloantibody.
Suciu-Foca N, Reed E, Rohowsky C, Kung P, King DW. 2017 Aug;189(2):138-157. doi: 10.1111/cei.12981. 1984;3(4):311-8. doi: 10.1007/BF02919049. Suciu-Foca N, Rohowsky-Kochan C, Reed E, Haars R, Bonagura V, King DW, Reemstma K. Surv Immunol Res. Possible mechanisms of immunotherapy for maintaining pregnancy in recurrent spontaneous aborters: analysis of anti-idiotypic antibodies directed against autologous T-cell receptors. Dahl et al. Breakdown of the maternal immune tolerance may result in fetal rejection. 1977 Aug;24(2):106-11 Anti-idiotypic autoimmunity--a necessity for species survival.
2010 Jan;59(1):63-70. doi: 10.1007/s00011-009-0070-2. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Operational tolerance in kidney transplantation and associated biomarkers. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. J Exp Med. The impact of pregnancy on the incidence of anti-HLA immunization has been poorly explored, and most of the data were obtained by standard complement-dependent lymphocytotoxicity (CDC) assay, with a reported incidence of 18% to 30% . As early as 4 weeks of gestation, semi-allogeneic fetal DNA can be detected in … The mothers and their offspring were typed for HLA-A, HLA-B, and HLA-DR. Sera from the mothers were studied using the Luminex screening test to detect anti-HLA class I … Some people may have these antibodies for other reasons as well. 1997 Jul;10(3):369-400. doi: 10.1128/CMR.10.3.369-400.1997. stimulate maternal anti-fetal acquired immunity if pa-ternal alleles differed from maternal. COVID-19 is an emerging, rapidly evolving situation. Curr Opin Immunol. 2010 Dec 1;10:77. doi: 10.1186/1471-2393-10-77. Maternal anti-HLA class I antibodies. They do not cause any harm to the body of the person making them and the person is not ill because of having them. Please enable it to take advantage of the complete set of features! Magliani W, Conti S, Gerloni M, Bertolotti D, Polonelli L. Clin Microbiol Rev. cate that the anti-HLA class I in nulliparous cases had an independent and additive effect on neonatal platelet counts, irrelevant of anti–HPA-1a level. | Get the latest research from NIH: https://www.nih.gov/coronavirus. 2010 Oct;22(5):669-81. doi: 10.1016/j.coi.2010.08.018. We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response.
Anti-HLA sensitization occurs after allogeneic contact, by prior transplantation, transfusions, and mainly pregnancy for women.
Clipboard, Search History, and several other advanced features are temporarily unavailable. 1986 Feb;15(2):211-9. doi: 10.1016/0198-8859(86)90027-3. The other HLA class I antigens expressed by trophoblast cells are HLA-E, -F, and -G. These class Ib antigens are NIH Due to the common occurrence of maternal anti-HLA class I during pregnancy,29,30 it is surprising that no pre-vious study has … A successful pregnancy requires an optimal interplay between the maternal immune system and the semi-allogeneic fetus. Anti-HLA receptors expressed by T and B lymphocytes seem to share serologic determinants because sera that bind to autologous alloactivated lymphoblasts are also capable of inhibiting the anti-HLA activity of autologous and homologous sera. They are more common in the blood of people who have had a blood transfusion or those who have been pregnant. N01-AI-82552/AI/NIAID NIH HHS/United States, NCI CPTC Antibody Characterization Program, Cancer Res. USA.gov. Yet allelic dispar-ity at the HLA-C locus does not seem to be a causal factor in infertility or termination of pregnancy. These antibodies are called human leukocyte antigen (HLA) antibodies. Antibodies against HLA antigens may form after an organ transplant, a blood transfusion or a pregnancy. Epub 2017 May 29. NLM
Verduin EP, Lindenburg IT, Smits-Wintjens VE, van Klink JM, Schonewille H, van Kamp IL, Oepkes D, Walther FJ, Kanhai HH, Doxiadis II, Lopriore E, Brand A. BMC Pregnancy Childbirth. Surface markers of lymphocyte activation in pregnant asthmatics. Suciu-Foca N, Rohowsky C, Kung P, King DW.
Bohács A, Pállinger E, Tamási L, Rigó J Jr, Komlósi Z, Müller V, Dong Y, Magyar P, Falus A, Losonczy G. Inflamm Res. This hypothesis has been confirmed in the present investigations which show that sera from parous women react with autologous T lymphoblasts primed in 5-day mixed lymphocyte culture against their husband-i.e., with lymphoblasts expressing receptors for the immunizing donor. We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response. 1973 Oct;33(10):2373-7 METHODS: Pregnancy-induced HLA sensitization was analyzed in 69 mothers without a history of transfusions or transplants. Based on this observation we have postulated that the absence of HLA antibodies in alloimmunized human subjects may be due to the development of autoantibodies that react with the anti-HLA receptors expressed by primed lymphocytes or by anti-HLA antibodies or both. Ito K, Tanaka T, Tsutsumi N, Obata F, Kashiwagi N. Hum Reprod.
Auto-anti-idiotypic antibodies inhibit the autologous mixed lymphocyte response to autologous alloactivated lymphoblasts, a phenomenon whose in vivo correlate may reside in autoinhibition of anti-HLA antibody formation and of allograft immunity. Get the latest public health information from CDC: https://www.coronavirus.gov. | Foetus expresses both maternally and paternally inherited HLA-C antigens. HHS 1982 Jul 1;156(1):283-8. doi: 10.1084/jem.156.1.283. -, Cold Spring Harb Symp Quant Biol.
1999 Mar;14(3):650-5. doi: 10.1093/humrep/14.3.650. Bonagura VR, Rohowsky-Kochan C, Reed E, Ma A, McDowell J, King DW, Suciu-Foca N. Hum Immunol. -. Anti-HLA antibodies produced in the body after pregnancy usually have no effect on the woman or on her subsequent pregnancies. This response is anti-idiotypic in nature because lymphocytes so primed display accelerated memory responses only when restimulated by autologous lymphoblasts that have been alloactivated against the same HLA-DR antigen. This site needs JavaScript to work properly. Idiotypic network regulations of immune responses to HLA.
1977;41 Pt 1:275-84 The passive transfer of antireceptor (idiotype) immunity by use of antibodies from pregnant women's sera may provide a powerful tool for specific suppression of allograft rejection. | If testing shows you have HLA antibodies, you may only be able to donate whole blood and red blood cells. 1976 Sep;8(3):349-53 Detection of anti-HLA antibodies in maternal blood in the second trimester to identify patients at risk of antibody-mediated maternal anti-fetal rejection and spontaneous preterm delivery. Increased level of maternal anti-HLA class I antibodies in thrombocytopenic neonates are associated with reduce foetal growth. Perturbation of the immune network in herpes gestationis.
Clatworthy MR, Espeli M, Torpey N, Smith KG.
Because auto-anti-idiotypic antibodies were found in sera from all parous women tested, the hypothesis that nonresponsiveness to alloantigens exists as a state per se is not likely. Thus, the maternal tolerance toward the fetus has to be maintained both locally at the fetal-maternal interface and systemically, since bidirectional trafficking of cells and soluble HLA between the mother and the fetus takes place (1–3). Massart A, Ghisdal L, Abramowicz M, Abramowicz D. Clin Exp Immunol. -, Transplantation. Long-Term follow up after intra-Uterine transfusionS; the LOTUS study. Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy.
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