The primary goal of treatment for MM is to achieve an early, deep, and durable response with an acceptable level of toxicity.
http://dx.doi.org/10.1016/s0145-2126(12)70003-6, Celgene Corporation. As patients with MM are surviving longer than ever before, patients will be exposed to more MM therapies during the course of their disease. Leukemia, 20(2), 193–199. Disease-a-Month, 58(4), 195–207. We're here to help. A percentage of MM patients do not respond to first-line novel agents, and many are not eligible for HSCT, which is the only potentially curative option in MM. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: A review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease. Multiple myeloma cancer life expectancy , Each form of cancer is characterized by an independent malignant growth of a specific cell type in the body…. Journal of the Advanced Practitioner in Oncology, 3, 209–224. (2013).
Thank you for sharing your insights.
When myeloma wakes, the patient and his medical team will have to consider the treatment to control the evolution of myeloma. We have had 4 drugs approved for myeloma since 2015 (two are new classes of drugs). Effective combination regimens are usually selected from the three major classes of drugs: The IMF's Chief Medical Office Dr. Jospeh Mikhael commented on these three major classes of drugs in this article in Cancer Therapy Advisor. Unfortunately, life expectancy after relapse averages about nine months. Seminars in Hematology, 49(suppl 1), S3–S15. Cancer Treatment Reviews, 37(4), 266–283. What is the life expectancy of someone with multiple myeloma? Dr. Anaissie has published a well written example of an exceptional supportive care model. http://dx.doi/org/10.1111/j.1365-2141.2011.08574.x, Sorror, M. L. (2013). The future of therapy for relapsed/refractory multiple myeloma: Emerging agents and novel treatment strategies.
National Comprehensive Cancer Network. http://dx.doi.org/10.1182/blood-2012-01-405985, Kuehl, W. M., & Bergsagel, P. L. (2012). Blade, J., Samson, D., Reece, D., Apperley, J., Bjorkstrand, B., Gahrton, G.,...Vesole, D. (1998). Is administered intravenously twice a week for two weeks, followed by a bye week that completes a cycle; the complete treatment usually consist of up to eight cycles. At the time they had over 10,000 transplants under their belt, and as a result they were expert at the process, and knew what could go wrong and had a plan in place to get you through any potential complications. Frailty and vulnerability has been found to correlate with unfavorable outcome. Nothing less than an ALL STAR performance.
As a result not all oncologists or hematologists are the same. http://dx.doi.org/10.1038/sj.thj.6200312, Eshaghian, S., & Berenson, J. R. (2012).
LaTalidomida is daily administered orally in pill form and can control the disease and reduce the amount of myeloma present in the body, thus relieving the symptoms and inducing even the entrance of the patient in a stable phase or plateau; in some cases it may even remission.
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