This is just one more way of ensuring your safety and that of our staff. The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure. HLA mismatches were not associated with acute or chronic GVHD, but were strongly associated with graft failure. Therefore, the monthly PRA gives us two very important pieces of information about the patient's serum: Since HLAantibody can "come and go", it is important to test for thePRA regularly. There are times when a closely matched donor isn’t the best option.
Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. Matching A Donor. Positive serum crossmatch as predictor for graft failure in HLA-mismatched allogeneic blood stem cell transplantation. The hazard ratio for mortality for single (7/8) and double mismatched (6/8) transplants was 1.29 (0.97-1.72; P = .079) and 1.82 (1.30-2.55; P = .0004), respectively, compared with 8/8 matched transplants. It is important in stem cell transplants to see how closely the HLA of the transplant patient matches the HLA of the stem cell donor.
performed statistics; and A.W.
HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection. The CIBMTR is supported by Public Health Service Grant/Cooperative Agreement U24-CA76518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID); Grant/Cooperative Agreement 5U01HL069294 from NHLBI and NCI; contract HHSH234200637015C with the Health Resources and Services Administration (HRSA/DHHS); grants N00014-06-1-0704 and N00014-08-1-0058 from the Office of Naval Research; and grants from Allos Inc; Amgen Inc; Angioblast; an anonymous donation to the Medical College of Wisconsin; Ariad; Be the Match Foundation; Blue Cross and Blue Shield Association; Buchanan Family Foundation; CaridianBCT; Celgene Corporation; CellGenix GmbH; Children's Leukemia Research Association; Fresenius-Biotech North America Inc; Gamida Cell Teva Joint Venture Ltd; Genentech Inc; Genzyme Corporation; GlaxoSmithKline; HistoGenetics Inc; Kiadis Pharma; The Leukemia & Lymphoma Society; The Medical College of Wisconsin; Merck & Co Inc; Millennium: The Takeda Oncology Co; Milliman USA Inc; Miltenyi Biotec Inc; National Marrow Donor Program; Optum Healthcare Solutions Inc; Osiris Therapeutics Inc; Otsuka America Pharmaceutical Inc; RemedyMD; Sanofi; Seattle Genetics; Sigma-Tau Pharmaceuticals; Soligenix Inc; StemCyte, A Global Cord Blood Therapeutics Co; Stemsoft Software Inc; Swedish Orphan Biovitrum; Tarix Pharmaceuticals; Teva Neuroscience Inc; THERAKOS Inc; and Wellpoint Inc. Unadjusted clinical outcomes by degree of HLA-A, -B, -C, -DRB1 matching.
ThePRA is determined by testing the patient's serum to a panel of 60 different types of HLA. As stated before, the patient could haveHLAantibody as a result of transfusions, prior transplants, and/or pregnancies.
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