The discovery of stem cell markers in other organ systems, such as the haematopoietic system, offers optimism that a marker of limbal stem cells will one day be found. Holoclones are identified by high expression of the marker p63 and are also known as p63 bright cells. Evaluation of CK3/CK12 and CK19 expression is currently used to confirm the diagnosis of LSCD by corneal impression cytology. HHS When the injury damaged only the ocular surface epithelium, including the limbus but sparing the corneal stroma, CLET was sufficient to restore corneal integrity and improve visual acuity; when the corneal stroma was involved by the injury, the corneal scarring required a subsequent keratoplasty for visual recovery [70] (Figure 4). Murine fertilized ovum, blastomere and morula cells lacking SP phenotype.
It is possible that other members of the ABC transporter family may be expressed in corneal epithelial SP cells allowing for the efflux of Hoechst 33342 and therefore the observed SP phenotype, but that these cells lack ABCG2 that is expressed in many tissue‐specific stem cells. In contrast, cells within the SP gate were barely detected in the corneal epithelium of rabbits (Fig. Two decades of experimental and clinical studies resulted in 70–80% success rates, and an improvement can be expected by identification of specific stem cell markers allowing a better biopsy procedure, sheet selection, and potentially enrichment of stem cell concentration.
| The corneal epithelium is a self-renewing tissue and must, by definition, have a resident basal cell population necessary for homeostasis and wound healing. Keratinocytes’ culture was originally developed for epidermal keratinocytes and has been used in the last two decades for restoration of the corneal surface on hundreds of patients with LSCD with no adverse effects [80]. googletag.cmd.push(function() { Oral Mucosal Epithelial Cells Grown on Porous Silicon Membrane for Transfer to the Rat Eye. eCollection 2018. //
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