Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. This regimen was meant for patients who had an HLA-identical sibling donor, and was evaluated in multiple myeloma patients. N Engl J Med. Biol Blood Marrow Transplant. This regimen was evaluated in the treatment of high-risk pediatric acute lymphoblastic leukemia in CR1. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.
In both cases, new stem cells are used to replace diseased tissues. Lancet. Marrow transplantation for patients with acute lymphoblastic leukemia in remission. Kohrt HE, Turnbull BB, Heydari K, Shizuru JA, Laport GG, Miklos DB, Johnston LJ, Arai S, Weng WK, Hoppe RT, Lavori PW, Blume KG, Negrin RS, Strober S, Lowsky R. TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blume KG, Beutler E, Bross KJ, Chillar RK, Ellington OB, Fahey JL, Farbstein MJ, Forman SJ, Schmidt GM, Scott EP, Spruce WE, Turner MA, Wolf JL. Sobol U, Rodriguez T, Smith S, Go A, Vimr R, Parthasarathy M, Guo R, Stiff P. Seven-year follow-up of allogeneic transplant using BCNU, etoposide, cytarabine and melphalan chemotherapy in patients with Hodgkin lymphoma after autograft failure: importance of minimal residual disease.
Epub 2013 Oct 3. As with many operations, allotransplantation also has some side effects. Syngeneic is a see also of allogeneic. 2005 Sep 29;353(13):1321-31.
You could also do it yourself at any point in time. 1979 Feb 15;300(7):333-7.
An allogenic bone marrow transplant can result in an immune attack on the recipient, called graft-versus-host disease. Unless otherwise specified, the day before HSCT is day -1, the day of HSCT is day 0, and the day after HSCT is day +1.
2016 Jan 29. 2002;8(3):145-54.
This regimen is meant for related donors; only 8 patients received this regimen before the addition of ATG (rabbit) after 2006. The transplant is called an allograft, allogeneic transplant, or homograft.Most human tissue and organ transplants are allografts. In the US, donor tissue must be recovered and processed adhering to the Current Good Tissue Practices rule. Cancer. Blood. The second, called the âDonor Eligibilityâ rule, proscribes criteria for donor eligibility.
Recipients of stem cells from matched unrelated donors also received: Alvarez I, Sureda A, Caballero MD, Urbano-Ispizua A, Ribera JM, Canales M, García-Conde J, Sanz G, Arranz R, Bernal MT, de la Serna J, Díez JL, Moraleda JM, Rubió-Félix D, Xicoy B, Martínez C, Mateos MV, Sierra J. Nonmyeloablative stem cell transplantation is an effective therapy for refractory or relapsed Hodgkin lymphoma: results of a Spanish prospective cooperative protocol. 1973 Aug;132(2):279-85.
2002;8(9):468-76.
(90)YFC: Ibritumomab tiuxetan, Fludarabine, Cyclophosphamide, Also known as sinusoidal obstructive syndrome (SOS). Allotransplant (allo- meaning "other" in Greek) is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. and Mielcarek et al. Thomas ED, Sanders JE, Flournoy N, Johnson FL, Buckner CD, Clift RA, Fefer A, Goodell BW, Storb R, Weiden PL. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. Rudolph RH, Fefer A, Thomas ED, Buckner CD, Clift RA, Storb R. Isogeneic marrow grafts for hematologic malignancy in man. 2003 Jul 15;21(14):2747-53. Slavin S, Nagler A, Naparstek E, Kapelushnik Y, Aker M, Cividalli G, Varadi G, Kirschbaum M, Ackerstein A, Samuel S, Amar A, Brautbar C, Ben-Tal O, Eldor A, Or R. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. 2005 (MRC UKALL XII/ECOG E2993), Antithymocyte globulin, horse ATG (Atgam), Ibritumomab tiuxetan & Yttrium-90 (Zevalin), https://hemonc.org/w/index.php?title=Allogeneic_HSCT&oldid=46176, About HemOnc.org - A Hematology Oncology Wiki, Seems to have inferior 1-year non-relapse mortality, Seems to improve 1 & 2 year NRM, similar OS, Suggested improved outcomes, but shorter follow up, Seems to have superior survival at day +100.
Epub 2003 Jun 5. Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H, Mellits D, Sensenbrenner LL, Stuart RK, Yeager AM. [3], a deceased person's body whose heart stopped beating, "Composite Tissue Allotransplantation and Reconstructive Surgery", https://web.archive.org/web/20160303183943/http://www.aatb.org/files/safetyoftissuetransplants.pdf, https://www.cdc.gov/ncidod/dhqp/tissueTransplantsFAQ.html#top, https://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/default.htm, https://web.archive.org/web/20101126080809/http://organdonor.gov/donor/registry.shtm, https://en.wikipedia.org/w/index.php?title=Allotransplantation&oldid=962502058, Creative Commons Attribution-ShareAlike License, Intestinal transplantation (isolated small bowel, intestine & liver, multivisceral).
2015 Jul;21(7):1299-307. doi: 10.1016/j.bbmt.2015.03.003. 2015 Feb 15;121(4):562-9. Note: abstract is limited in detail including which days the treatments are given. It is contrasted with autotransplantation (from one part of the body to another in the same person), syngeneic transplantation of isografts (grafts transplanted between two genetically identical individuals of the same species) and xenotransplantation (from other species). Treatment of chronic granulocytic leukemia with chemoradiotherapy and transplantation of marrow from identical twins. N Engl J Med. Erratum in: Cancer. 1998 Feb 1;91(3):756-63.
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