contact us. © 2020 MJH Life Sciences™ and Cure Today. Conquer Cancer Foundation 2015 Nov;29(6):387-403. doi: 10.1016/j.blre.2015.06.001. Again, consideration of quality of life for these patients is paramount. Summary of the Most Relevant Studies Establishing a Relation Between CR or MRD Negativity and Outcomes. DOI: 10.1200/EDBK_175171 American Society of Clinical Oncology Educational Book Patients in the final category do not desire to proceed to high-dose melphalan consolidation. 1The current treatment options for frail patients were discussed, along with classification systems, and potential future directions for therapies. Keywords: M is a plasma cell malignancy that occurs among older adults and accounts for 15% of all hematologic malignancies in the United States.1 The median age of diagnosis is 69 years; in the next 15 years, MM incidence is expected to double.2,3 Thirty-five percent of patients are diagnosed at age 75 or older, including 10% at age 85 older.4 Novel therapeutics and routine use of ASCT have led to substantial improvements in patient survival. Puig et al91 demonstrated that among newly diagnosed patients treated according to the PETHEMA/GEM2005MAS65 protocol (including VMP or VTP as induction followed by VT or VP as maintenance), those with a molecular CR after induction had a PFS not yet reached, whereas patients with MRD positivity had a significantly shorter PFS (median 31 months; p = .03). Zweegman S., Larocca A., Management of Elderly Patients with MM.
delivered to your inbox every month. Which regimens are best for this population? The median PFS and OS for the total cohort, and for each frailty group, are shown in COVID-19 is an emerging, rapidly evolving situation. However, fewer than 20% of all patients age 65 or older are undergoing the procedure.13, In 2015, at age 65, the average man would be expected to live 17.9 more years on average, compared with 18 more years for a woman; at age 70, a man would be expected to live 14.1 more years on average, compared with 16.3 more years for a woman.5 The depth of response is shown to increase survival both in the frontline and salvage settings and among both transplant-eligible and transplant-ineligible patients; this is particularly true for complete remissions and is now being shown for attainment of an MRD state.71-76 Thus, pursuing high-dose melphalan with ASCT as a strategy that will allow for a deeper response for older patients is appropriate as long as the expected morbidity and mortality of the transplant process is acceptable. Blood Rev. J Clin Oncol. This retrospective study analyzed the outcomes of 366 patients (median age: 69 years) treated in South Korea between 2007 and 2017.
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