eCollection 2020. Byun JM, Yoon SS, Koh Y, Min CK, Lee JH, Jo J, Park H, Lee J, Kang KW, Lee Y; and the Korean Multiple Myeloma Working Party (KMMWP). Dental Management of the Organ or Stem Cell Transplant Patient. Blood. The role of high-dose melphalan and autologous stem cell transplant in the rapidly evolving era of modern multiple myeloma therapy. Current research in Stem Cell Transplantation (SCT) focuses on improving transplant outcome through immune manipulations using cell therapy and lymphocyte growth factors. Who is most suited to undergo ASCT?
More Information - Stem Cell Allogeneic Transplantation For 207 consecutive MM patients who underwent Auto-SCT and were 70 years or older at transplant (study cohort), data were analyzed and compared with a younger cohort (1764 Auto-SCT patients <70 years old). 2018 Mar 7;19(1):169. doi: 10.1186/s13063-018-2524-8. More than 30 years after its introduction, autologous stem cell transplantation (ASCT) remains the standard of care for young patients with newly diagnosed multiple myeloma. This site needs JavaScript to work properly. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest. M.M. Controversies in multiple myeloma: to transplant or not? NCI CPTC Antibody Characterization Program, Harousseau JL, Moreau P. Autologous hematopoietic stem-cell transplantation for multiple myeloma.
Stem cell transplantation is a generic term covering several different techniques (see fig fig1). -, Barlogie B, Hall R, Zander A, Dicke K, Alexanian R. High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. What’s more, stem cells harvested in this way have qualities that appear to increase the odds of transplant success. Publication files. -.
NIH Stem Cell Research Severe Aplastic Anemia and Myelodysplastic Syndrome.
Clin Adv Hematol Oncol. 1987;70:869–872. In … These are some of the questions addressed in this review which we will attempt to answer with the latest currently available data. Please enable it to take advantage of the complete set of features! Optimizing carfilzomib use in multiple myeloma treatment. High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Such improvements are now on the horizon.NIH-funded researchers recently found that, at least in mice, a single injection of two complementary treatments can generate enough stem cells in 15 minutes [1]. Is there an age threshold that should not be surpassed? More than 30 years after its introduction, autologous stem cell transplantation (ASCT) remains the standard of care for young patients with newly diagnosed multiple myeloma. In most dicotyledonous species, the underlying stem cell niche, the cambium, generates xylem inwards and phloem outwards. Novel agent use is now inarguably essential in induction, maintenance, and possibly consolidation.
2020 Jan;82:101929. doi: 10.1016/j.ctrv.2019.101929. -, McElwain TJ, Powles RL. Minimal Residual Disease in Multiple Myeloma: Current Landscape and Future Applications With Immunotherapeutic Approaches.
Not only did the arrival of novel agents such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PI) and monoclonal antibodies not replace ASCT, instead they solidified its central role as standard of care. Get the latest public health information from CDC: https://www.coronavirus.gov. Autologous stem cell transplant (Auto-SCT) is increasingly used in older patients with multiple myeloma (MM), despite lack of phase 3 trials in this age-defined population. View NIH staff guidance on coronavirus (NIH Only): https://employees.nih.gov/pages/coronavirus/, Organ or Stem Cell Transplant and Your Mouth, Dental Management of the Organ or Stem Cell Transplant Patient, https://employees.nih.gov/pages/coronavirus/, Advancing the nation's oral health through research and innovation, The Quest to Understand Dental Stem Cells, Mid-Career Funding Helps Scientists Answer Big Questions. Should transplantation be embarked on early or is it reasonable to delay it? Cardiooncology.
Ntanasis-Stathopoulos I, Gavriatopoulou M, Kastritis E, Terpos E, Dimopoulos MA. Epub 2019 Sep 25. doi: 10.1056/NEJMct0805626. Epub 2019 Nov 11. 2020 May 12;11:2040620720921046. doi: 10.1177/2040620720921046. Clin Adv Hematol Oncol. Current research in Stem Cell Transplantation (SCT) focuses on improving transplant outcome through immune manipulations using cell therapy and lymphocyte growth factors. Download Treatment of autologous stem cell transplant-eligible multiple myeloma patients: ten questions and answers. COVID-19 is an emerging, rapidly evolving situation. NIH research is progressing on multiple fronts to learn more about the differences between the 3 stem cell types and to create patient-specific cells for in-depth study of many diseases. What is the role of tandem transplantation in the era of novel agents and where do patient-specific cytogenetics come into the equation when deciding on treatment?
Radial growth of plant shoots and roots is a stem cell-driven process that is fundamental for the mechanical and physiological support of enlarging plant bodies. Incorporating hematopoietic stem-cell transplantation after second-line carfilzomib-lenalidomide-dexamethasone (KRd). Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.
Striha A, Ashcroft AJ, Hockaday A, Cairns DA, Boardman K, Jacques G, Williams C, Snowden JA, Garg M, Cavenagh J, Yong K, Drayson MT, Owen R, Cook M, Cook G. Trials. The role of ixazomib as an augmented conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT consolidation and maintenance strategy in patients with relapsed multiple myeloma (ACCoRd [UK-MRA Myeloma XII] trial): study protocol for a Phase III randomised controlled trial. Ma LL, Liu Y, Jia SX, Lv HC, Fang MY, Xia YL. Haematologica. 2020 Mar 13;6:4. doi: 10.1186/s40959-020-0059-0. doi: 10.1016/S0140-6736(83)90739-0. 2019 Sep;54(3):159-161. doi: 10.5045/br.2019.54.3.159. Multiple myeloma: Role of autologous transplantation. Kostopoulos IV, Ntanasis-Stathopoulos I, Gavriatopoulou M, Tsitsilonis OE, Terpos E. Front Oncol. discloses lectures honoraria and research support from Amgen, Celgene, Janssen, Sanofi, and Takeda whose products are discussed in this work. 2019 Aug 1;125(15):2534-2543. doi: 10.1002/cncr.32060. Get the latest oral health information from CDC: https://www.cdc.gov/oralhealth
Thus, plant stem cells may be ranked among the most important cells for human well-being. N. Engl. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cancer. 1983;2:822–824. 2019 Oct;17(10):559-568. | 1986;67:1298–1301. NLM
2014;99:408–416.
Most patients with SAA or … What are the optimal induction, consolidation, and maintenance therapies? Curr Hematol Malig Rep. 2014 Dec;9(4):360-7. doi: 10.1007/s11899-014-0230-5. -, Barlogie B, et al. Blood Res. eCollection 2020. -, Mohty M, Harousseau JL. Blood. Not only did the arrival of novel agents such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PI) and monoclonal antibodies not replace ASCT, instead they solidified its central role as standard of care. 2009;360:2645–2654. Epub 2019 Apr 15. Research by many labs in the last decades has uncovered a set of independent stem cell systems that fulfill the specialized needs of plant development and growth in four dimensions. Receive automatic alerts about NHLBI related news and highlights from across the Institute. Delaying the use of high-dose melphalan with stem cell rescue in multiple myeloma is ready for prime time. HHS In light of these new advancements, new challenges arise in deciding on optimal practice. Ther Adv Hematol. Researchers at the National Institutes of Health (NIH) are testing ways to make transplant using unrelated donor cells from umbilical cord blood safer and more effective.
Is there still a role for stem cell transplantation in multiple myeloma? doi: 10.3324/haematol.2013.096149. NIH Surprisingly, the cellular and molecular design of these systems is remarkably similar, even across diverse species.
J. Med. | High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Get the latest public health information from CDC: https://www.coronavirus.gov 1).Allogeneic transplants are haemopoietic stem cells from the bone marrow, peripheral blood, or umbilical cord blood of a healthy donor matched for HLA type, who may be a family member or an unrelated volunteer. 2020 May 27;10:860. doi: 10.3389/fonc.2020.00860. See this image and copyright information in PMC. Cancer Treat Rev. Lancet.
Treatment of severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) usually involves a bone marrow transplant. Get the latest research information from NIH: https://www.nih.gov/coronavirus eCollection 2020. | COVID-19 is an emerging, rapidly evolving situation. Get the latest research from NIH: https://www.nih.gov/coronavirus.
USA.gov. U.S. Department of Health & Human Services, COVID-19 is an emerging, rapidly evolving situation, Get the latest public health information from CDC, Get the latest research information from NIH, Get the latest information and resources from NHLBI, NIH staff guidance on coronavirus (NIH Only), Obesity, Nutrition, and Physical Activity, NHLBI Diversity, Equity and Inclusion Statement, Customer Service/Center for Health Information. 2016 Sep;14(9):719-28.
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