Targeting β1-integrin inhibits vascular leakage in endotoxemia. The promise of mesenchymal stem cell therapy for acute respiratory distress syndrome.
Mesenchymal stromal cell homing: mechanisms and strategies for improvement.
Stem Cells Transl Med. Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery. Lancet.
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.
2014;15:39. https://doi.org/10.1186/1465-9921-15-39. Privacy
Fischer UM, Harting MT, Jimenez F, et al. Gene Ther. Cookies policy.
The SARS-CoV-2 virus enters the respiratory tract.
Similar to SARS-CoV, the S protein of SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) and enters cells in a manner catalyzed by transmembrane protease serine 2 (TMPRSS2) protease in type II alveolar epithelial cells [4, 5]. MSCs are considered to have broad clinical application prospects, including as a treatment for ARDS. 2018;84:183–91. Matthay et al. Text in a red font color indicates COVID-19-associated effects. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. 2008 Dec 1;68(23):9614-23. doi: 10.1158/0008-5472.CAN-08-0451.
Google Scholar. Stem Cell Res Ther. CAS Hypothesis for the management and treatment of the COVID-19-induced acute respiratory distress syndrome and lung injury using mesenchymal stem cell-derived exosomes. | We are committed to sharing findings related to COVID-19 as quickly as possible. Rojas M, Xu J, Woods CR, et al.
Precision medicine for cell therapy in acute respiratory distress syndrome. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (STARS study): a randomised phase 2a safety trial.
2020. https://doi.org/10.1016/j.mehy.2020.109865. Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release.
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Impact and Challenges of Mesenchymal Stem Cells in Medicine: An Overview of the Current Knowledge, Department of Oncology, Stem Cells and Nanomedicine, California Innovations Corporation, La Jolla, San Diego, CA 92037, USA, Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran, Department of Cell Biology, University of Freiburg, Freiburg, Germany, Institute for Macromolecular Chemistry, Faculty of Chemistry and Pharmacy, BIOSS-Centre for Biological Signalling Studies, Stefan-Meier Strasse 31, Hermann Staudinger Haus, University of Freiburg, Freiburg D-79104, Germany, https://www.hindawi.com/journals/sci/si/152812/cfp/, Glial cell line-derived neurotrophic factor, Major histocompatibility complex (either class I or II), Stromal cell-derived factor 1-alpha (or CXCL12), Single photon emission computed tomography, I. Ullah, R. B. Subbarao, and G. J. Rho, “Human mesenchymal stem cells - current trends and future prospective,”, S. Shahrokhi, S. Daneshmandi, and F. Menaa, “Tumor necrosis factor-α/CD40 ligand-engineered mesenchymal stem cells greatly enhanced the antitumor immune response and lifespan in mice,”.
https://doi.org/10.1073/pnas.1722317115. The IL-6 level on day 5 showed a downward trend compared with that of day 0, but it was not statistically significant (p = 0.06). Bone marrow-derived mesenchymal stem cells in repair of the injured lung. This work was supported by grants from the Clinical Research Support Fund of PLA General Hospital (2018FC-WJFWZX-1-03) and from the Military Medical Technologies Young Scientist Cultivate Project (20QNPY099). Lancet Respir Med. Atluri S, Manchikanti L, Hirsch JA.
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Thanuja MY, Anupama C, Ranganath SH. Mesenchymal Stem Cells.
2020. https://doi.org/10.1038/s41591-020-0868-6. Review articles are excluded from this waiver policy.
Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. 2020;395:497–506.
COVID-19: the vasculature unleashed.
At present, over 20 clinical trials of MSCs in treating COVID-19 are in progress, including clinical trials based on MSC derivatives. 2014;3:10. https://doi.org/10.1186/2001-1326-3-10. The S protein on the surface of the virus binds to the secretory cells of the nasal epithelium and the membrane protein ACE2, which is highly expressed in bronchoalveolar type II cells. Stem Cells Dev. https://doi.org/10.1016/S2213-2600(14)70291-7. https://doi.org/10.1016/j.isci.2019.05.004. Lancet Respir Med. All authors read and approved the final manuscript. MSCs can reduce the production of proinflammatory cytokines, which may alleviate the cytokine storm induced by SARS-CoV-2, and increase the production of IL-10, which can reduce the inflow and aggregation of neutrophils in the lung and reduce the production of TNF-α [37].
2020. https://doi.org/10.1093/cvr/cvaa106. Cancers (Basel). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
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2018;132:57–80. For instance, homing of MSCs involves CXCR4 and SDF-1 alpha but the exact mechanism is still unclear to avoid off-target homing; (vi) the precise mechanism(s) by which MSCs regulate the immune response is/are also undefined.
Handb Exp Pharmacol.
Med Hypotheses.
Among these, the administration of MSCs is considered to be a promising approach for the treatment of ARDS in different respiratory viral infection models.
[38]. Stem Cell Research & Therapy The beneficial effects of MSCs are mainly dependent on paracrine mechanisms [33].
Cell. Gene-modified MSC are useful as therapeutic tools for brain tissue damage (e.g. All clinical trial data were accessed from the Project Data Sphere platform ClinicalTrials.gov (https://clinicaltrials.gov/). The virus-induced production of proinflammatory cytokines, including TNF-α and CXCL-10, was inhibited after MSC treatment [27]. ; Rationale for Recommendation. Mesenchymal stromal cells (MSCs) have been reported to be promising treatments for lung diseases. Cite this article.
EV, extracellular vesicles; NETs, neutrophil extracellular traps; Treg, regulatory T cells; AT-II, alveolar type II; ROS, reactive oxygen species; FGF7, fibroblast growth factor 7; Ang-1, angiopoietin-1.
In a follow-up study, Simonson et al. Springer Nature. | Meng SS, Xu XP, Chang W, et al.
CAS Stem Cells. Another study found that after infection with COVID-19, MSC treatment inhibited the overactivation of the immune system and promoted endogenous repair by improving the lung microenvironment.
Chillà A, Margheri F, Biagioni A, Del Rosso T, Fibbi G, Del Rosso M, Laurenzana A. https://doi.org/10.1165/rcmb.2004-0330OC.
Mesenchymal stem cells (MSCs) possess a set of several fairly unique properties which make them ideally suited both for cellular therapies/regenerative medicine, and as vehicles for gene and drug delivery.
MSCs promote epithelial and endothelial repair, alveolar fluid clearance, and bacterial clearance and exert anti-inflammatory and antiapoptotic effects. Because stem cells are resistant to tissue damage, promote tissue repair, and have immunoregulatory effects, research by scientists worldwide in the field of stem cells is bringing hope for a treatment for respiratory virus-induced pneumonia [25]. 2018;9:280. https://doi.org/10.1186/s13287-018-1031-x. PubMed
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The key mechanisms include paracrine mechanisms, extracellular vesicles, or direct contact of cells with metastatic cell contents. Hahn JY, Cho HJ, Kang HJ, Kim TS, Kim MH, Chung JH, Bae JW, Oh BH, Park YB, Kim HS. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Currently, only a few reports have detailed the response of patients with acute respiratory distress syndrome to MSCs (Table S2). Although refined research techniques have been applied, the effectiveness of MSC engraftment is still not satisfactory. Introduction to Mesenchymal Stem Cells. 2010;84:12658–64. The accumulation of inflammatory cells in turn leads to the production of a large number of proinflammatory cytokines, known as a cytokine storm.
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