NIH Molecular profiling of beige adipocytes shows them to be similar to primary BAs isolated from human tissue. Int J Mol Sci. High-throughput screening for small molecule activators of beige adipocytes. Under the cold effect, white adipose tissue may present cells like brown adipocytes called ‘beige’ or “brite” adipocytes. Nous Those cells seem to be able to participate to the thermogenesis even if, physiologically speaking, there is no evidence of their implications. R01 AR070178/AR/NIAMS NIH HHS/United States, American Diabetes Association. Engrafted human beige adipocytes increase glucose clearance and heat generation. Ces résultats, publiés dans la revue Cell, permettent de comprendre l’origine de ces cellules et laissent entrevoir de nouvelles stratégies thérapeutiques de lutte contre le surpoids et l’obésité.
Those cells seem to be able to participate to the thermogenesis even if, physiologically speaking, there is no evidence of their implications. Au sein de notre organisme, nous avons trois types de tissu graisseux, composé de différents types d'adipocytes (cellules graisseuses). This organ which main role is adaptive thermogenesis has the ability to dissipate energy through heat. These findings demonstrate the potential utility of BAs as a cell therapeutic and as a tool for the identification of drugs to treat metabolic diseases. Although several reports have described the generation of beige adipocytes in vitro, their potential utility in cell therapy and drug discovery has not been reported. Bienvenue sur EM-consulte, la référence des professionnels de santé.L’achat d’article à l’unité est indisponible à l’heure actuelle. Nouvelle découverte dans l'élimination des graisses. 5. Elsevier Masson SAS. La recherche est en cours, espérons que de nouvelles voies s’ouvriront à nous. Cells. Beige adipocyte transplantation increases energy expenditure, oxygen consumption, and reduces body weight and…, Fig.
has potential competing interests through association with Thermoceutics LLC. Fig. Ces derniers espèrent rapidement pouvoir appliquer à l’homme les résultats obtenus chez la souris. Ces cellules beiges, que l’on retrouve dans des dépôts de la taille d’une noix situés sous la peau, près des clavicules et le long de la colonne vertébrale, ont pour principale fonction la production de chaleur (thermogenèse). -, American Diabetes Association. Ces cellules se trouvent dans le tissu adipeux blanc. Although several reports have described the generation of beige adipocytes in vitro, their potential utility in cell therapy and drug discovery has not been reported.
2013;19:1252–1263. High-throughput screening for small molecule…. An essential characteristic of beige adipocytes is its dynamic regulation of the thermogenic gene program by external stimuli. Mais, en attendant, le plus important est de garder un bon équilibre alimentaire, de faire un peu d’exercice et de bien gérer son stress.
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