Mesenchymal stem cells (MSCs) are a safe and promising biologic therapeutic for promoting tissue repair in ischemic and non-ischemic heart disease.
Comparison of autologous and allogeneic stem cell therapy.
On the other hand, autologous transplant uses the patient’s own stem cells. While these companies do not represent all cell therapy companies, the breakdown of autologous versus allogeneic cell therapy development among these market leaders is important to consider and reflective of broader trends across the cell therapy marketplace. Unlike autologous therapy, allogeneic manufacturing is not limited by on-demand manufacturing.
Allogeneic therapies are manufactured in large batches from unrelated donor tissues (such as bone marrow) whereas autologous therapies are manufactured as a single lot from the patient being treated.
While early and with plenty of caveats, Allogene's data offer at least the potential that a cancer cell therapy derived from healthy donors might be a viable alternative to autologous CAR-T treatments, which are made from the cells of cancer patients. Copyright © 2016 Elsevier Inc. All rights reserved.
A stem cell transplant is a procedure during which doctors either replace diseased or ineffective stem cells with healthy new stem cells or allow high-dose treatment for lymphoma, some testicular cancers, and other diseases.
Allogeneic treatments seek to overcome challenges by using engineered cells from healthy donors.
Allogeneic versus Autologous Cell Therapy Companies. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. There exist two types of stem cell transplant: autologous and allogeneic.
Whether it is a stem cell treatment, a bone marrow transplant, or any other type of therapy, allogeneic means “from another person” while autologous means “from oneself.” Allogeneic versus Autologous. Stem Cell and Gene Therapy for Cardiovascular Disease, https://doi.org/10.1016/B978-0-12-801888-0.00012-6. Allogeneic transplant uses new stem cells from a different donor. The immune-evasive properties of MSCs permit their use in allogeneic therapy, which offers the benefit of immediate availability and the appropriate number of cells. Furthermore, the allogeneic transplant has a higher risk of graft failure, graft rejection, life threatening complications, treatment-related mortality, etc., than an autologous transplant. Allogeneic stem cell therapy offers advantages during the autologous counterpart.
Copyright © 2020 Elsevier B.V. or its licensors or contributors. By continuing you agree to the use of cookies. The stem cells are derived from young healthy donors, eliminating any comorbidities associated with disease states. The mechanisms underlying the salutary effects of MSCs include multilineage differentiation potential, immunomodulatory effect, anti-fibrotic effect, and stimulation of neovascularization and endogenous progenitor cell proliferation and differentiation.
The primary difference between allogeneic and autologous are the source of the cells for the therapy.
In other words, the treatment can be made in advance—hence the name “off-the-shelf.” In addition, combination stem cell therapy is emerging as a strategy to improve the therapeutic potential of MSCs. This is the key difference between allogeneic and autologous transplant. A growing number of clinical trials support the notion that both autologous and allogeneic MSC therapy is safe and has the capacity for repair of the myocardium. It is often lifesaving for patients with blood cancer and serious blood disorders. Studies are underway to determine the best tissue source of MSCs and the optimal number of cells, route(s) of delivery, and timing of the intervention. We use cookies to help provide and enhance our service and tailor content and ads.
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