doi: 10.2217/17460751.3.1.1. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. (a) Scanning electron microscopy image of PLA-PPy scaffold (left) without sputtered gold layer and PLA scaffold (right) with 20 nm gold coating. ASCs also have the potential to treat various diseases, such as graft-versus-host disease [12], autoimmune-induced diseases [13, 14], multiple sclerosis [15], diabetes mellitus [16], and tracheomediastinal fistulas [17]. Although no structural or functional analysis was performed, immunohistochemical staining revealed myocardial engraftment of ASCs with concomitant expression of myosin heavy chain, troponin I, and the transcription factor Nkx2.5.92. eCollection 2020. They are broadly multipotent and have less ethical issues compared to ESCs [41]. Get the latest public health information from CDC: https://www.coronavirus.gov. Gao et al. Jeong Hoon Heo.
The osteo medium presented a darker purple color than that of the basal medium, which was consistent with the quantitative results shown in Figures 3(c) and 3(d). Jeon, J.-H. Lee et al., “The effect of silicon ion on proliferation and osteogenic differentiation of human ADSCs,”, I.-S. Yoon, C. W. Chung, J.-H. Bioprinting methods also help to maintain the differentiation potential of ASCs. Besides, it is easy to obtain ASCs using the minimally invasive liposuction [47], and the percentage of obtained cells is relatively higher than other stem cell sources [47]. Maintaining biochemical, biomechanical, and biological properties during proliferation is also important to withstand the external environment impact [29]. (a) Scanning electron microscopy image of PLA-PPy scaffold (left) without sputtered gold layer and PLA scaffold (right) with 20 nm gold coating. Before seeding the cells, scaffolds containing β-TCP granules (porosity, 60%; granule size, 1.4–2.8 mm) were fabricated for cell attachment. In vitro study showed that metformin that is introduced to the culture medium at concentration equal 500 µM may promote the differentiation of rASCs into bone-forming cells, which express mRNA and secrets proteins that are related to the functional tissue (namely, alkaline phosphatase and osteocalcin).
A PubMed search of “cardiac disease” and “stem cells” from 1996 to present returns over 1000 hits; adding the term “clinical trials” returns over 60 hits. The proliferation of ASCs in polypyrrole-coated polylactide (PLA-PPy) and PLA scaffolds has been investigated [61]. ASCs cocultured with human umbilical vein endothelial cells (HUVEC) in collagen/alginate microspheres could be used as a biomimetic physiological model. J.M.G. Ligands for the PPARγ transcription factor include natural (long-chain fatty acids, prostaglandin J2) and synthetic (thiazolidinedione) compounds,14 and, in vitro, these agents can induce liposarcoma-derived cells to differentiate into adipocytes.15 Based on these observations, physicians have used oral thiazolidinediones to treat patients with liposarcomas, thereby reducing cell proliferation and increasing expression of adipocyte gene markers.16,17 Although it remains to be determined whether ligand-induced adipogenesis is an effective chemotherapy for patients with liposarcoma, the work is consistent with the hypothesis that liposarcomas derive from a stem cell progenitor.
The qualitative level of ALP was assessed by staining the fixed samples with nitro-blue tetrazolium/indolyl phosphate. It occupies space no longer required for hematopoiesis and serves as an energy reservoir and cytokine source for osteogenic and hematopoietic events. Adipose secretion of adiponectin, leptin, resistin, and other adipokines exerts systemic physiological and pathological effects. Author information: (1)School of Engineering, University of British Columbia, Kelowna, BC, Canada V1V 1V7; West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.
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