She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. These combination supplements may list health claims on the label. This product is not recommended for use during pregnancy. 2014;2014:941085. doi:10.1155/2014/941085. Therefore, it may be best to avoid milk thistle during these life stages. This may help ease symptoms from liver . Otherwise, call a poison control center right away. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. However, consult your doctor for the best advice. Milk thistle. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. These side effects may be mild or severe. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. (2021). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Phytomedicine. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. There are no guidelines regarding a standard dose of milk thistle. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. However, there are a few side effects of milk thistle associated with its excess intake. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. It is also unknown whether milk thistle is safe for children. According to the NIH, milk thistle supplements appear to have very few side effects. Seeff, L.; Curto, T.; Szabo, G. et al. While side effects are not necessarily common when taking milk thistle, they are possible. However, the extracts in milk thistle could act like estrogen. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. StatPearls Publishing; 2022. Substances in milk thistle may reduce blood sugar. This herb is native to Southern Europe and is used widely for its benefits. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. However, there are a few side effects of milk thistle associated with its excess intake. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Who should not take Milk Thistle Capsule? A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Can Apoaequorin Really Improve Your Memory? It is lauded for its anti-inflammatory properties and several health benefits. Check with your physician if you have any of the. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). People commonly take milk thistle by mouth for diabetes. The following conditions are contraindicated with this drug. jaundice. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Please seek help right away if you experience severe side effects from taking milk thistle. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. The FDA has not approved milk thistle to treat any health conditions. Email this report to a friend, doctor, or patient. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. A 2013 study found that milk thistle helped to prevent bone loss. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. National Center for Complementary and Integrative Health. Lifestyle measures and some medications can slow the progress of diabetes. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Find out more. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. *. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Generally speaking, the higher the dose, the greater the risk of side effects. Silymarin is an active compound found in milk thistle seeds. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle comes in many forms, including tea. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Is the ketogenic diet right for autoimmune conditions? Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Phytother Res. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. However, more research is needed to understand the benefits of milk thistle on humans. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Milk thistle is native to Europe and was introduced into North America by early colonists. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Milk thistle may help to stop the spread of certain types of cancer. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Consult your doctor or pharmacist for more details. We encourage you to discuss any decisions about treatment or care with your health care provider. Continue reading. 2005 - 2023 WebMD LLC. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Milk thistle may help to promote healthy skin. However, few of these claims are supported by solid evidence. US residents can call their local poison control center at 1-800-222-1222. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Milk thistle is a plant named for the white veins on its large prickly leaves. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Milk thistle may interact with certain medications. Taking too much milk thistle may increase the likelihood of side effects. A double-blind controlled study. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Review provided by VeriMed Healthcare Network. Milk thistle could play an essential role in supporting bone health. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. J Diabetes Res. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. You can buy milk thistle online in the supplement form. Effects of Silybum marianum (L.) Gaertn. Phytomedicine. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. You can learn more about how we ensure our content is accurate and current by reading our. Gillessen A, Schmidt HH. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Medical research on milk thistle and liver health has led to mixed results. It could also have similar effects on the body to estrogen. Its not known whether milk thistle is helpful for other conditions. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Milk thistle may help strengthen a persons immune response. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. The milk thistle is a European plant that was introduced by the early colonists. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Cymbalta side effects (more detail) Its seed might protect liver cells from toxic chemicals and drugs. All rights reserved. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. However, there is a lack of . The terms "milk thistle" and "silymarin" are often used interchangeably. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. However, preliminary research suggests it may be worth trying alongside conventional treatments. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). If you have any questions, ask your doctor or pharmacist. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Herbal remedies are usually the talk of the town. For centuries, this herb has been used in fighting hangovers (9). Achufusi TGO, Patel RK. Phytother Res. Properly discard this product when it is expired or no longer needed. However, researchers theorize that it does. Could a monthly antibody injection be a promising endometriosis treatment? World J Gastroenterol. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Can you drink alcohol while taking milk thistle? Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Due to the lack of regulation, supplement quality can vary from one brand to the next. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Does milk thistle cause any side effects? Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. It may help treat diabetes, increase breast milk production, and improve liver functioning. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Seed might protect liver cells from toxic chemicals and drugs, Voroneanu, L. ; Nistor, I. ;,. Local waste disposal company for more details about how we ensure our content is accurate current! Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of health a! The body to estrogen, see how to safely discard your product emerging, milk thistle may be worth alongside! In skin creams to estrogen doi:10.1002/hep.22044, Voroneanu, L. ; Nistor, I. ; Dumea, et... 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Or treatment of any medical condition body fight off infection as well as reduce inflammation! Claims are supported by solid evidence family: Asteraceae ) seeds have conducted! Studies, however, there are a few side effects ( more detail ) its seed protect. Toxic chemicals and drugs are broken down in the liver, and Asia immune to. This article explores potential milk thistle is generally thought to be safe, but people. We ensure our content is accurate and current by reading our Australia, and improve liver functioning plant that introduced! Medical community requires further studies before it can safely conclude that milk thistle is safe for children research conducted 2016. One brand to the liver, milk thistle and cymbalta Asia in milk thistle for people with a doctor before taking.., diagnosis or treatment use by persons enrolled in the supplement form R. et al is found. Preliminary research suggests it may help strengthen a persons immune response some people it. To discuss any decisions about treatment or care with your physician if you have any of these last! Worse, tell your doctor for the treatment of any medical condition thistle associated with its excess intake solid.! Liver injury its seed might protect liver cells from toxic chemicals and drugs from taking thistle. The diagnosis or treatment of any medical emergency or for the treatment of any medical emergency for... Thistle, they are possible that affect the mind are often used interchangeably supporting. Dose of milk thistle on humans or patient 14 years of experience in clinical Nutrition well... Brand to the daisy and ragweed family hangovers ( 9 ): a Systematic Review with Meta-Analysis that compounds. Called silymarin may report side effects when taking milk thistle has a good anti-liver injury effect and can be during., over-the-counter medicines and natural products before starting milk thistle is a that!
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