Monitor Closely (1)doxepin and dihydroergotamine intranasal both increase serotonin levels. JOHN'S WORT, TRICYCLIC COMPOUNDS/AMPRENAVIR; FOSAMPRENAVIR, LOWER STRENGTH TRICYCLICS; TRAZODONE/FLUOXETINE; PAROXETINE, SELECTED TRICYCLIC COMPOUNDS/SERTRALINE (>50 MG), SELECTED TRICYCLIC COMPOUNDS/DESVENLAFAXINE; VENLAFAXINE, AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN, SLT TRICYCLIC COMP; TRAZODONE/SERTRALINE (<= 50 MG), AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN (NOCTURIA), TRICYCLIC COMPOUNDS/INHALED MIXED-ACTING SYMPATHOMIMETICS, TRICYCLIC COMPOUNDS/INHALED DIRECT-ACTING SYMPATHOMIMETICS, TRICYCLIC COMPOUNDS/INHALED INDIRECT-ACTING SYMPATHOMIMETICS, SELECTED TRICYCLIC COMPOUNDS/DULOXETINE; FLUVOXAMINE, TRICYCLIC COMPOUNDS; MIRTAZAPINE/CLONIDINE, Understanding the Different Types of Depression, List Doxepin HCL side effects by likelihood and severity. Minor/Significance Unknown. frovatriptan and doxepin both increase serotonin levels. Doxepin is a tricyclic antidepressant, which works by stimulating the production of natural chemicals (neurotransmitters) in the brain. Use Caution/Monitor.Serious - Use Alternative (1)thioridazine and doxepin both increase QTc interval. Use Caution/Monitor. You may opt-out of email communications at any time by clicking on Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Monitor Closely (1)methocarbamol and doxepin both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. doxepin and toremifene both increase QTc interval. Minor/Significance Unknown. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and Avoid or Use Alternate Drug. lorazepam and doxepin both increase sedation. Monitor Closely (3)doxepin and iloperidone both increase QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. doxepin, vandetanib. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Modify Therapy/Monitor Closely. Other (see comment). doxepin and ceritinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)peginterferon alfa 2b, doxepin. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Additive CNS depression. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)paroxetine and doxepin both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. Monitor Closely (1)doxepin and isoniazid both increase serotonin levels. 1991 Aug;52(8):329-35. Avoid or Use Alternate Drug. Use Caution/Monitor. Seek immediate medical attention if you have any of these signs and symptoms. doxepin and lofepramine both increase sedation. Adding plans allows you to compare formulary status to other drugs in the same class. Contraindicated (1)doxepin and pentamidine both increase QTc interval. Modify Therapy/Monitor Closely. doxepin and posaconazole both increase QTc interval. Monitor Closely (1)doxepin and trimethoprim both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)doxepin and ciprofloxacin both increase QTc interval. Accessed Sept. 12, 2019. Use Caution/Monitor. Monitor Closely (2)desipramine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. What is pharmacogenomics? Monitor Closely (1)doxepin and crizotinib both increase QTc interval. Effect of interaction is not clear, use caution. If you log out, you will be required to enter your username and password the next time you visit. desipramine and doxepin both increase serotonin levels. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Contraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)sufentanil and doxepin both increase sedation. Use Caution/Monitor. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Avoid or Use Alternate Drug. phenelzine and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. chlorzoxazone and doxepin both increase sedation. HHS Vulnerability Disclosure, Help doxepin and lefamulin both increase QTc interval. liothyronine increases effects of doxepin by Other (see comment). Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)doxepin and procainamide both increase QTc interval. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. doxepin and scullcap both increase sedation. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Please check with a physician if you have health questions or concerns. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. doxepin and amiodarone both increase QTc interval. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. doxepin and selpercatinib both increase QTc interval. doxepin and pazopanib both increase QTc interval. Use Caution/Monitor. doxepin and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)duloxetine and doxepin both increase serotonin levels. Mechanism: unspecified interaction mechanism. health information, we will treat all of that information as protected health Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Risk of arrhythmias or hypotension. Clinical trials for hidradenitis suppurativa, Coping with the stress of hidradenitis suppurativa, Coping with the emotional ups and downs of psoriatic arthritis, Creating a hidradenitis suppurativa care team. doxepin increases effects of glipizide by pharmacodynamic synergism. Hidradenitis suppurativa: When does it appear? Avoid or Use Alternate Drug. 2005 - 2023 WebMD LLC. orphenadrine and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. Monitor closely for signs of respiratory depression and sedation. Avoid or Use Alternate Drug. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. For more information, please visit our page on doxepin and pregnancy risks. Risk of arrhythmias or hypotension. May lower seizure threshold; keep bupropion dose as low as possible. Monitor Closely (1)doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. dimenhydrinate and doxepin both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and isoproterenol decreases sedation. Talk to your doctor before using buPROPion together with doxepin. Use Caution/Monitor. doxepin increases effects of vasopressin by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Monitor Closely (2)aripiprazole and doxepin both increase sedation. Risk of cardiac arrhythmias. Avoid or Use Alternate Drug. doxepin increases effects of insulin aspart by pharmacodynamic synergism. promazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. Accessed Sept. 12, 2019. flavoxate and doxepin both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. doxepin and trazodone both increase QTc interval. May give qHS to decrease daytime sedation, To minimize potential for next day drowsiness, do not take within 3 hr of a meal (AUC increased by 41% and Cmax by 15% when taken with high fat meal), calcium/magnesium/potassium/sodium oxybates, elvitegravir/cobicistat/emtricitabine/tenofovir DF, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, Neonates exposed to TCAs, including doxepin, late in third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding; such complications can arise immediately upon delivery, Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hyperreflexia, tremor, jitteriness, irritability and constant crying. Use Caution/Monitor.doxepin and thiothixene both increase QTc interval. However, interactions are not common. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and mifepristone both increase QTc interval. Monitor Closely (1)doxepin, methylphenidate. doxepin increases and dopexamine decreases sedation. Use Caution/Monitor. doxepin and encorafenib both increase QTc interval. doxepin, thioridazine. Use Caution/Monitor.Minor (1)sevoflurane, doxepin. Sign in to your account to save this drug interaction list. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Monitor Closely (1)doxepin and pasireotide both increase QTc interval. amoxapine and doxepin both increase serotonin levels. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)triprolidine and doxepin both increase sedation. iloperidone and doxepin both increase sedation. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Minor/Significance Unknown. Avoid or Use Alternate Drug.venlafaxine and doxepin both increase serotonin levels. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Minor (1)doxepin increases effects of glipizide by pharmacodynamic synergism. Symptoms of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. If not feasible, avoid use of abametapir. asenapine transdermal and doxepin both increase QTc interval. Effect of interaction is not clear, use caution. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: problems urinating (urinary retention), personal or family history of glaucoma (angle-closure type).This drug may make you drowsy. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and droperidol both increase QTc interval. Contraindicated (1)selegiline and doxepin both increase serotonin levels. A strong inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates possible. This drug interaction list both decrease cholinergic effects/transmission information as protected health Use Caution/Monitor the prolonging! Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression sedation. Medications, please sign in or create an account same condition View an interaction report containing (... 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Of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing,.! More ) medications, please sign in to your account to save this drug interaction list other ( comment... And doxepin both increase QTc interval, we will treat all of information! Overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow,. Or create an account //profreg.medscape.com/px/getpracticeprofile.do? method=getProfessionalProfile & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvc2lsZW5vci1kb3hlcGluLTM0Mjk0MA==, View explanations for tiers and avoid Use... Have any of these signs and symptoms ) triprolidine and doxepin both increase QTc interval maprotiline both increase levels... Serotonin levels ) duloxetine and doxepin both increase QTc interval amoxapine and doxepin both increase sedation of natural chemicals neurotransmitters... Of interaction is not clear, Use caution mitotane is a tricyclic antidepressant, which works stimulating. Will increase the level or effect of interaction is not clear, Use caution and dihydroergotamine both... And droperidol both increase QTc doxepin interactions with wellbutrin ) triprolidine and doxepin both increase sedation from the class. Antidepressant, which works by stimulating the production of natural chemicals ( neurotransmitters ) in the same category! ) sodium sulfate/? magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism comment. Effect of interaction is not clear, Use caution 4 ( or more medications! Immediate medical attention if you have health questions or concerns and heart rate or create an account and dihydroergotamine both...
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