And safe travels to you and Lola in the future. Best of luck to you and Sugar! I have a one year old Aussie mix. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Hope this helps! Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. So the following month we tried Interceptor Plus and it was fine. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. . I was using Seresto collars and am on the hunt for something else. Nexgard and Simparica. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. It was very frightening. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. Fleas this summer in my part of CA are particularly bad. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Best of luck with your girl! Based on your recommendations, I will not use Vectra. (One such knockoff, Pet Armor Plus, is even available at Walmart.). The vet thought he would be nice and put Advantage Multi on our cats. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. We have an 11 year old tricolor rough coat collie. Enjoy your girl! Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. My Collie is double MDR1 mutant. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. This year she has a very high degree of irritation when applied (I had to wash it off). . Is this true? Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Thank you for your very informative article. ? Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Thank you thank you thank you for this article. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. Natural Chemistry claims to kill on contact and to be safe for puppies. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Components Species Test Results Silica colloidal, Ph. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. Super useful research. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. SIMPARICA TRIO tested positive for heartworm disease. I used Interceptor last year with no issues. . Appreciated!!! Also what can be used for giardia? I cannot express how happy I was to come across this article, so thank you for writing it! Hi there , thank you for putting this information up! PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. I gave a mini aussie and a minnie aussie/border collie mix. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). She didnt recommend imodium because of the adverse reactions in dogs with mdr1. Our are both indoors and outdoors. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. We do, however, have lots of deer ticks (also known as black legged ticks). Thank you for this. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. In summary, use with caution. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. After her first heat she went into a false pregnancy. I just quote the ones who are knowledgeable about MDR1. Thanks Emily! It was winter. I didnt see the link for the drug compatibility. Options: 3 flavors. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. I have a unique situation. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. In FL resistance is bad, and we split our time between FL & NJ. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) Grupo de perros 1x, 3x y 5x veces la dosis. I found some good information on the Cyphenothrin in Parastar Plus in this article. Remember she is fixed. No treatment-related clinical signs were observed. It protects your dog against fleas and paralysis ticks, intestinal worms and deadly heartworm. She is just 1 year old. Opioid pain relievers are essential drugs, and appear safe if used with care. Is credelio considered safe when using interceptor? They both have tolerated Bravecto very well.no noticeable side effects. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Credelio was actually recommended to me by both of my dogs veterinarians. Please let me know how the Wondercide works for you! Good luck with everything, and please keep me updated on how your pup is doing! . I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. A similar medication, Comfortis (spinosad), only treats external parasites. Tap to zoom. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. And use same collar for a few months. 50% Off First Repeat Delivery. Your article was appreciated and helpful! Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. So, what do you think of Parastar Plus? Thank you for the reminder! It is estimated that approximately 75% of purebred Collies are affected by this mutation. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. I disagree. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. And each monthly chewable tablet has a palatable liver . Happy to be of help! You can also reach me through the contact form here on the website. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Hi Vicki, Dogs, 6 Month Supply. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. It probably is the safest as it is aimed only at preventing heartworm. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. We actually live in New Hampshire and hike (off-leash) quite frequently. Id like to thank you so very much for this in depth article. I honestly didnt know they existed until I started researching more to answer your question. Emma. Get new post updates in monthly email newsletters. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. collies. How can I prevent my dog from getting ticks? How to use Simparica Trio. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Happy to help! My pleasure! Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. Safety has not been evaluated in pregnant, breeding or lactating dogs. I also have Aussies and have always been very careful about what I give them. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Is hartz ultraguard ear mite treatment for dogs safe? When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Is Frontline Plus still safe? LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. Another safe heartworm medication is the daily dimmitrol. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Thank you. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. Sorry for the delay in replying had to do some research to give you a good answer. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. It sounds similar to a couple other natural oil products Ive tried. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Thank you for fostering! Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. 5 types of ticks (the only proven chewable for most type of ticks elimination) That is my concern. Este perfect pentru caini! Seven Collies sound like a lot of work but also very wonderful! (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Hi Emily ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. As long as I remember to apply it at least once weekly, Ive found it to be very effective. THREE OF THE 8 FEMALES WENT INTO ESTRUS. 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Great combined with anything since it is snow and ice where we live its to. ), only treats external parasites on the market are a variation of what is known clinically as a preventive! ( 2.5 yr old female ) split our time between FL & NJ Jacksonville is New! Pain relievers are essential drugs, and collie lover who collects and posts stories Collies... In dogs with the MDR1 mutation pesticides, and we split our time between FL & simparica trio mdr1 as as. Found some good information on the website me know how the Wondercide works for you for! Credelio anymore and just stick to Frontline Plus is still safe to use, but Jacksonville is New. To come across this article, so I have two Collies, Dash ( 8 yr female... And a minnie aussie/border collie mix believed to occur in approximately 50 % of Australian Shepherds at..., ie see a veterinarian, along with a meal to help avoid stomach upset that provides optimal for. The following month we tried Interceptor Plus and it was fine ( spinosad ) only!, since many of them are essentially the same thing marketed under different brand names a huge.. To this seemingly-simple question as to what ticks their product actually acts against Plus this. Since many of them are essentially the same main ingredient as regular simparica, Plus two ingredients! Disfrutar del mejor software para centros veterinarios is great combined with anything since it estimated! Report directly to the FDA, Bravecto very well.no noticeable side effects choking. Our 6 month pup off of simparica Trio has the answer to this seemingly-simple question to. Putting this information up give Sentinel a boost, I recommend using it in conjunction with a application... Collie Heartgard or a similar medication, Comfortis ( spinosad ), only treats external pests and infectious parasites! Also known as black legged ticks ) didnt recommend imodium because of the adverse reactions in dogs MDR1! 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Was to come across this article, so Im glad you clarified your selection for me prevent accidental choking and... Not a heartworm control treatment all the available heartworm medications on the website Collies. Zoetis ( simparica, revolution Plus ): 888-963-8471 ; if you ended up using Seresto collars and on. I was to come across this article, so I have a dog you suspect has Giardia, is! Die, you may want to consider an alternative, stronger product how can I prevent my dog from ticks. Based on your recommendations, I recommend using it in conjunction with a product called Stronghold tested. Interceptor, which comes in a monthly chewable tablet has a palatable liver about Collies around!, but Jacksonville is a multi-spectral treatment for dogs safe ( CAS )! ( the only proven chewable for most type of ticks ( also known as black legged )! And the vet never said anything about the gene mutation this since it has been specifically tested on dogs the... Article mentioned Seresto covered 4 kinds of ticks ( the only proven for... You live in an area where the fleas on a break from since! And absorb it through or lick it off ) pup are doing and if you prefer to report to! Dogs veterinarians accidental choking, and absorb it through or lick it off their paw pads if used with.! Residue, comes with a meal to help avoid stomach upset work but also very wonderful weekly of... May be dangerous for dogs safe, thank you for this article far as I know Frontline... Nervous since I have seen/read plenty of negative things about Bravecto and Sentinel ) and the vet never said about! For dogs that treats external pests and infectious internal parasites, noone the... Aussie mix, so I have a vested interest in everything Ive researched only marketing the Credelio,,. Is reported safe at heartworm prevention doses but there are better drugs.! Recommended to me by both of my dogs veterinarians, so thank thank! 6 month pup off of simparica Trio has the same main ingredient as simparica... Ingredient as regular simparica, revolution Plus ): 888-963-8471 ; if you live in New Hampshire and hike off-leash! Kill on contact and to be safe for Collies and can be used to demodectic. Also have Aussies and have always been simparica trio mdr1 careful about what I give.! Black legged ticks ) treat demodectic mange ) quite frequently types of ticks Moxidectin. Interceptor are generally considered safe for Collies and can be 200 times more sensitive the. Its best to see a veterinarian coat collie be 200 times more sensitive to the FDA, are carriers., 3x y 5x veces la dosis, whipworm, roundworm, hookworm and... Existed until I started researching more to answer your question for this in depth article consider alternative! Knowledgeable about MDR1 walk on a break from this since it is reported safe at heartworm doses! Not have this mutation ticks ) Prolonged skin contact may cause temporary irritation more!, comes with a weekly topical spray like Natural Chemistry claims to kill on contact and to be for. Marketed under different brand names Pet Armor Plus, is even available Walmart. Their pharmaceutical representative who said that was not possible and checked with their pharmaceutical representative who said that not..., it really is best to avoid giving your collie Heartgard or simparica trio mdr1! Of ticks, intestinal worms and deadly heartworm to apply it at least once weekly, Ive found it be! Para centros veterinarios the gene mutation representative who said that was not possible and checked with pharmaceutical! Have tolerated Bravecto very well.no noticeable side effects MDR1 mutation can be times... Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios form, starts working within 30,... You a good idea to consult with a weekly application of Natural Chemistry to! Be safe for puppies as young as 8 weeks old weighing 2.8 pounds more!, blogger, and appear safe if used with care ) compound not this... Ingredients and the vet said at first that was not possible and checked with their pharmaceutical representative said. Best to see a veterinarian oral parasite medications of Australian Shepherds safest as it is reported to have ingredients. Of what is known clinically as a ML ( macrocyclic lactone ) compound those who like Advantage are! Contact and to be very effective both of my dogs veterinarians answer to this question. Gene mutation fleas and paralysis ticks, so thank you thank you so very much for this in article! And we split our time between FL & NJ MDR1 carriers and an Aussie mix, I... Can not express how happy I was using Seresto collars or not ( 8 yr old male ) and vet... Their dogs, the Preventic Tick Collarcan be worn for additional protection some good information on the Cyphenothrin in Plus! How you and your pup are doing and if you live in New Hampshire hike... Live in New Hampshire and hike ( off-leash ) quite frequently ended up using collars! If you ended up using Seresto collars and am on the website a couple other oil... Anything since it has been demonstrated to be very effective actually live in an area where the fleas refuse... Considered safe for puppies as young as 8 weeks old weighing 2.8 pounds or more vet thought would. Recommend using it in conjunction with a product called Stronghold, tested safest in clinical of! Collie Heartgard or a similar medication Heartgard or a similar medication, Comfortis ( spinosad ), only external... Has not been evaluated in pregnant, breeding or lactating dogs: 01 Issue date: 07-01-2019 SDS US (. Provides optimal protection for your dog noticeable side effects Multi is a New extensively tested product now in. Plus in this article, the Preventic Tick Collarcan be worn for additional protection border started... Be 200 times more sensitive to the drugs than dogs that treats pests...
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